{"title":"丹参多糖及其硫酸化衍生物的结构特征和免疫调节活性","authors":"Yongshuai Jing, Dongbo Liu, Yuwei Zhang, Shilin Zhang, Beibei Hu, Yinghua Xie, Zhiwei Li","doi":"10.1016/j.jff.2024.106452","DOIUrl":null,"url":null,"abstract":"<div><p>A polysaccharide (PSMP2) was isolated from <em>Salvia miltiorrhiza</em>, and its sulfated derivative (PSMP2-S) was synthesized. The chemical structures of PSMP2 and PSMP2-S were analyzed by various chemical analysis methods and instrumental analysis methods. The ultrastructures and thermal stability were further investigated. In addition, PSMP2 and PSMP2-S had strong immunomodulatory activity and could regulate cytokines (interleukin-2, interleukin-6 and tumor necrosis factor-α), increased the content of short chain fatty acids and effectively reduced the relative abundance of <em>Bacteroides</em> and increased the relative abundance of <em>Firmicutes</em>, significantly increase <em>Muribaculaceae</em> and <em>Lactobacillaceae</em>, and inhibit <em>Lachnospiraceae</em> and <em>Ruminococcaceae</em>, improve the composition of gut microbiota. This study showed that PSMP2 and PSMP2-S might be used as potential natural immune regulators and gut microbiota regulators, and had great development value in the field of food and medicine.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756464624004547/pdfft?md5=7166773be51b439f5830590bed2b0108&pid=1-s2.0-S1756464624004547-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Structural characterization and immunomodulatory activity of a polysaccharide from Salvia miltiorrhiza and its sulfated derivative\",\"authors\":\"Yongshuai Jing, Dongbo Liu, Yuwei Zhang, Shilin Zhang, Beibei Hu, Yinghua Xie, Zhiwei Li\",\"doi\":\"10.1016/j.jff.2024.106452\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A polysaccharide (PSMP2) was isolated from <em>Salvia miltiorrhiza</em>, and its sulfated derivative (PSMP2-S) was synthesized. The chemical structures of PSMP2 and PSMP2-S were analyzed by various chemical analysis methods and instrumental analysis methods. The ultrastructures and thermal stability were further investigated. In addition, PSMP2 and PSMP2-S had strong immunomodulatory activity and could regulate cytokines (interleukin-2, interleukin-6 and tumor necrosis factor-α), increased the content of short chain fatty acids and effectively reduced the relative abundance of <em>Bacteroides</em> and increased the relative abundance of <em>Firmicutes</em>, significantly increase <em>Muribaculaceae</em> and <em>Lactobacillaceae</em>, and inhibit <em>Lachnospiraceae</em> and <em>Ruminococcaceae</em>, improve the composition of gut microbiota. This study showed that PSMP2 and PSMP2-S might be used as potential natural immune regulators and gut microbiota regulators, and had great development value in the field of food and medicine.</p></div>\",\"PeriodicalId\":360,\"journal\":{\"name\":\"Journal of Functional Foods\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1756464624004547/pdfft?md5=7166773be51b439f5830590bed2b0108&pid=1-s2.0-S1756464624004547-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Functional Foods\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1756464624004547\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Foods","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756464624004547","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Structural characterization and immunomodulatory activity of a polysaccharide from Salvia miltiorrhiza and its sulfated derivative
A polysaccharide (PSMP2) was isolated from Salvia miltiorrhiza, and its sulfated derivative (PSMP2-S) was synthesized. The chemical structures of PSMP2 and PSMP2-S were analyzed by various chemical analysis methods and instrumental analysis methods. The ultrastructures and thermal stability were further investigated. In addition, PSMP2 and PSMP2-S had strong immunomodulatory activity and could regulate cytokines (interleukin-2, interleukin-6 and tumor necrosis factor-α), increased the content of short chain fatty acids and effectively reduced the relative abundance of Bacteroides and increased the relative abundance of Firmicutes, significantly increase Muribaculaceae and Lactobacillaceae, and inhibit Lachnospiraceae and Ruminococcaceae, improve the composition of gut microbiota. This study showed that PSMP2 and PSMP2-S might be used as potential natural immune regulators and gut microbiota regulators, and had great development value in the field of food and medicine.
期刊介绍：
Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies.
The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients.
The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.
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