Ashton D. Hall , Joshua M. Ferreri , Jennifer E. Baker , Eleanor A. Powell , Imran Ahmed , Timothy T. Klostermeier , Keith M. Luckett
{"title":"累及大脑、胆囊、心脏和软组织的梭状芽孢杆菌气性坏疽:病例报告和文献综述","authors":"Ashton D. Hall , Joshua M. Ferreri , Jennifer E. Baker , Eleanor A. Powell , Imran Ahmed , Timothy T. Klostermeier , Keith M. Luckett","doi":"10.1016/j.idcr.2024.e02073","DOIUrl":null,"url":null,"abstract":"<div><p>Clostridial gas gangrene (CGG) is among the most rapidly spreading infections in humans, with mortality rates approaching 100 % if not treated promptly. Most cases follow traumatic inoculation, although spontaneous infections occur in a minority of patients with immunodeficiency. Spontaneous CGG is primarily caused by <em>Clostridium septicum</em>, whereas traumatic infection is associated with <em>Clostridium perfringens</em>. Patients with CGG present abruptly with rapidly progressive symptoms, underscoring the importance of early recognition, prompt surgical intervention, and appropriate antimicrobial therapy. We describe an illustrative case of spontaneous CGG caused by <em>C. perfringens</em> in a polymorbid 73-year-old female patient. Despite aggressive medical and surgical management, she succumbed to metastatic infection within 48 h of presentation.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"38 ","pages":"Article e02073"},"PeriodicalIF":1.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001495/pdfft?md5=0f086d239b55083580bb1cff5f7ad56d&pid=1-s2.0-S2214250924001495-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Clostridial gas gangrene involving the brain, gallbladder, heart, and soft tissue: A case report and literature review\",\"authors\":\"Ashton D. Hall , Joshua M. Ferreri , Jennifer E. Baker , Eleanor A. Powell , Imran Ahmed , Timothy T. Klostermeier , Keith M. Luckett\",\"doi\":\"10.1016/j.idcr.2024.e02073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Clostridial gas gangrene (CGG) is among the most rapidly spreading infections in humans, with mortality rates approaching 100 % if not treated promptly. Most cases follow traumatic inoculation, although spontaneous infections occur in a minority of patients with immunodeficiency. Spontaneous CGG is primarily caused by <em>Clostridium septicum</em>, whereas traumatic infection is associated with <em>Clostridium perfringens</em>. Patients with CGG present abruptly with rapidly progressive symptoms, underscoring the importance of early recognition, prompt surgical intervention, and appropriate antimicrobial therapy. We describe an illustrative case of spontaneous CGG caused by <em>C. perfringens</em> in a polymorbid 73-year-old female patient. Despite aggressive medical and surgical management, she succumbed to metastatic infection within 48 h of presentation.</p></div>\",\"PeriodicalId\":47045,\"journal\":{\"name\":\"IDCases\",\"volume\":\"38 \",\"pages\":\"Article e02073\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2214250924001495/pdfft?md5=0f086d239b55083580bb1cff5f7ad56d&pid=1-s2.0-S2214250924001495-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IDCases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214250924001495\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IDCases","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214250924001495","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Clostridial gas gangrene involving the brain, gallbladder, heart, and soft tissue: A case report and literature review
Clostridial gas gangrene (CGG) is among the most rapidly spreading infections in humans, with mortality rates approaching 100 % if not treated promptly. Most cases follow traumatic inoculation, although spontaneous infections occur in a minority of patients with immunodeficiency. Spontaneous CGG is primarily caused by Clostridium septicum, whereas traumatic infection is associated with Clostridium perfringens. Patients with CGG present abruptly with rapidly progressive symptoms, underscoring the importance of early recognition, prompt surgical intervention, and appropriate antimicrobial therapy. We describe an illustrative case of spontaneous CGG caused by C. perfringens in a polymorbid 73-year-old female patient. Despite aggressive medical and surgical management, she succumbed to metastatic infection within 48 h of presentation.