甲壳动物免疫防御中的细胞死亡

IF 8.8 1区 农林科学 Q1 FISHERIES
Zeyan Chen, Muhammad Tayyab, Defu Yao, Jude Juventus Aweya, Zhihong Zheng, Xianliang Zhao, Zhongyang Lin, Yueling Zhang
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引用次数: 0

摘要

甲壳动物的细胞死亡机制是一个复杂的相互作用过程,对维持细胞平衡和免疫防御至关重要。细胞凋亡、坏死和坏死等细胞死亡模式在甲壳类动物中已得到充分证明,它们在清除受损或受感染细胞方面发挥着至关重要的作用。与其他生物不同的是,甲壳类可能缺乏热凋亡,这是一种与先天免疫和炎症相关的程序性细胞死亡,因为它们不具备这一过程所必需的气体蛋白基因。最近,NETosis 和 ferroptosis 成为病原体防御的重要机制。NETosis涉及DNA纤维和抗菌蛋白的释放,有助于捕获和中和病原体,而ferroptosis是一种依赖铁的细胞死亡形式,有助于脂质过氧化和免疫反应。尽管尚未对杯突症进行甲壳动物免疫方面的研究,但它与铁突症之间存在潜在的相互影响,特别是在调节金属离子平衡、氧化应激和细胞代谢方面。了解这些机制为水产养殖业提供了广阔的应用前景,例如开发有针对性的免疫调节剂和增强具有重要经济价值的甲壳类物种的抗病能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell Death in Crustacean Immune Defense

Cell death mechanisms in crustaceans are a complex interplay of processes essential for maintaining cellular homeostasis and immune defense. Modes of cell death like apoptosis, necroptosis, and necrosis are well-documented in crustaceans, serving crucial roles in removing damaged or infected cells. Unlike in other organisms, crustaceans likely lack pyroptosis, a type of programmed cell death associated with innate immunity and inflammation, because they do not possess the gasdermin genes essential for this process. Recently, NETosis and ferroptosis have emerged as significant mechanisms in pathogen defense. NETosis, involving the release of DNA fibers and antimicrobial proteins, helps trap and neutralize pathogens, while ferroptosis, an iron-dependent form of cell death, contributes to lipid peroxidation and immune responses. Cuproptosis, although not yet studied in the context of crustacean immunity, shows potential crosstalk with ferroptosis, particularly in the regulation of metal ion homeostasis, oxidative stress, and cellular metabolism. Understanding these mechanisms offers promising applications in aquaculture, such as developing targeted immune modulators and enhancing disease resistance in economically important crustacean species.

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来源期刊
CiteScore
24.80
自引率
5.80%
发文量
109
审稿时长
>12 weeks
期刊介绍: Reviews in Aquaculture is a journal that aims to provide a platform for reviews on various aspects of aquaculture science, techniques, policies, and planning. The journal publishes fully peer-reviewed review articles on topics including global, regional, and national production and market trends in aquaculture, advancements in aquaculture practices and technology, interactions between aquaculture and the environment, indigenous and alien species in aquaculture, genetics and its relation to aquaculture, as well as aquaculture product quality and traceability. The journal is indexed and abstracted in several databases including AgBiotech News & Information (CABI), AgBiotechNet, Agricultural Engineering Abstracts, Environment Index (EBSCO Publishing), SCOPUS (Elsevier), and Web of Science (Clarivate Analytics) among others.
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