增强软骨细胞细胞内胆固醇外流可缓解骨关节炎的进展

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-09-11 DOI:10.1002/art.42984

Gyuseok Lee, Jiye Yang, Su-Jin Kim, Thanh-Tam Tran, Sun Young Lee, Ka Hyon Park, Seung-Hee Kwon, Ki-Ho Chung, Jeong-Tae Koh, Yun Hyun Huh, Jong-Keun Seon, Hyun Ah Kim, Jang-Soo Chun, Je-Hwang Ryu

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引用次数: 0

摘要

骨关节炎（OA）是全球最常见的退行性疾病，目前尚无切实可行的预防方法，治疗方案也很有限。最近，我们的研究小组发现了一种导致 OA 发病的新机制，它与软骨细胞中胆固醇代谢异常有关。在这项研究中，我们的目标是建立血脂状况与人类 OA 之间的临床联系，评估降低胆固醇药物抑制小鼠 OA 发生的有效性，并揭示有效阻碍 OA 进展的降低胆固醇机制。

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Enhancing intracellular cholesterol efflux in chondrocytes alleviates osteoarthritis progression

Osteoarthritis (OA) is the most common degenerative disease worldwide with no practical means of prevention and limited treatment options. Recently, our group unveiled a novel mechanism contributing to OA pathogenesis in association with abnormal cholesterol metabolism in chondrocytes. In this study, we aimed to establish a clinical link between lipid profiles and OA in humans, assess the effectiveness of cholesterol-lowering drugs in suppressing OA development in mice, and uncover the cholesterol-lowering mechanisms that effectively impede OA progression.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.