增强脑机接口的生物兼容性：综述

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2024-09-11 DOI:10.1016/j.bioactmat.2024.08.034

Jordan Villa , Joaquin Cury , Lexie Kessler , Xiaodong Tan , Claus-Peter Richter

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引用次数: 0

摘要

体内植入微电极为研究神经回路以及通过直接电刺激和记录恢复受损神经通路打开了大门。尽管一些神经假体已取得临床成功，但电极材料特性、炎症反应以及电极-组织界面的胶质疤痕形成都会影响其性能和可持续性。这些挑战可以通过改善材料的一些机械、物理、化学和电气特性来解决。本文回顾了当前微电极的材料和设计，并探讨了提高神经义肢性能的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Enhancing biocompatibility of the brain-machine interface: A review

查看原文本刊更多论文

Enhancing biocompatibility of the brain-machine interface: A review

In vivo implantation of microelectrodes opens the door to studying neural circuits and restoring damaged neural pathways through direct electrical stimulation and recording. Although some neuroprostheses have achieved clinical success, electrode material properties, inflammatory response, and glial scar formation at the electrode-tissue interfaces affect performance and sustainability. Those challenges can be addressed by improving some of the materials' mechanical, physical, chemical, and electrical properties. This paper reviews materials and designs of current microelectrodes and discusses perspectives to advance neuroprosthetics performance.

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.