Audun Olav Dahlberg , Audun Aase , Harald Reiso , Rune Midgard , Hanne Quarsten
{"title":"在 11 位将其持续性健康问题归咎于蜱媒疾病的人中检测到米库雷氏新 埃希氏菌","authors":"Audun Olav Dahlberg , Audun Aase , Harald Reiso , Rune Midgard , Hanne Quarsten","doi":"10.1016/j.ttbdis.2024.102391","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><em>Neoehrlichia mikurensis</em> infections can cause symptomatic disease, particular among immunosuppressed persons. Long-lasting asymptomatic carriage of <em>N. mikurensis</em> may be common in endemic areas. This study explores possible associations between carriage of <em>N. mikurensis</em> DNA and persistent health complaints in persons who attribute their symptoms to a tick-borne disease.</p></div><div><h3>Methods</h3><p>Eleven persons tested positive for <em>N. mikurensis</em> DNA by PCR in a study cohort of 285 persons reporting persistent health complaints. The 11 persons were tested again in a follow-up sample. Oral doxycycline treatment was given if the confirmatory PCR-test was positive. Treatment response was assessed by telephone interview. Demographics, clinical manifestations, tick exposure, physical health, somatic symptom burden and fatigue were compared to persons with negative <em>N. mikurensis</em> PCR (controls, <em>N</em> = 274).</p></div><div><h3>Results</h3><p>Six persons had detectable <em>N. mikurensis</em> DNA in a follow-up sample up to 9.5 months after the index sample. Seven persons (one without a positive confirmative test) received doxycycline treatment. Three reported symptom restitution after completed antibiotic treatment. However, their symptoms were not clearly attributed to infection by <em>N. mikurensis</em>. We did not find any significant differences between infected persons and non-infected controls regarding their clinical manifestations and health burdens.</p></div><div><h3>Conclusions</h3><p>We corroborate previous evidence of long-term carriage of <em>N. mikurensis,</em> but cannot infer that to be causative of persistent health complaints.</p></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 1","pages":"Article 102391"},"PeriodicalIF":3.1000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1877959X24000840/pdfft?md5=0d9739b3a6a8cb3dd6b4f91de0b76cb8&pid=1-s2.0-S1877959X24000840-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Detection of Neoehrlichia mikurensis in 11 persons who attribute their persistent health complaints to a tick-borne disease\",\"authors\":\"Audun Olav Dahlberg , Audun Aase , Harald Reiso , Rune Midgard , Hanne Quarsten\",\"doi\":\"10.1016/j.ttbdis.2024.102391\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><em>Neoehrlichia mikurensis</em> infections can cause symptomatic disease, particular among immunosuppressed persons. Long-lasting asymptomatic carriage of <em>N. mikurensis</em> may be common in endemic areas. This study explores possible associations between carriage of <em>N. mikurensis</em> DNA and persistent health complaints in persons who attribute their symptoms to a tick-borne disease.</p></div><div><h3>Methods</h3><p>Eleven persons tested positive for <em>N. mikurensis</em> DNA by PCR in a study cohort of 285 persons reporting persistent health complaints. The 11 persons were tested again in a follow-up sample. Oral doxycycline treatment was given if the confirmatory PCR-test was positive. Treatment response was assessed by telephone interview. Demographics, clinical manifestations, tick exposure, physical health, somatic symptom burden and fatigue were compared to persons with negative <em>N. mikurensis</em> PCR (controls, <em>N</em> = 274).</p></div><div><h3>Results</h3><p>Six persons had detectable <em>N. mikurensis</em> DNA in a follow-up sample up to 9.5 months after the index sample. Seven persons (one without a positive confirmative test) received doxycycline treatment. Three reported symptom restitution after completed antibiotic treatment. However, their symptoms were not clearly attributed to infection by <em>N. mikurensis</em>. We did not find any significant differences between infected persons and non-infected controls regarding their clinical manifestations and health burdens.</p></div><div><h3>Conclusions</h3><p>We corroborate previous evidence of long-term carriage of <em>N. mikurensis,</em> but cannot infer that to be causative of persistent health complaints.</p></div>\",\"PeriodicalId\":49320,\"journal\":{\"name\":\"Ticks and Tick-borne Diseases\",\"volume\":\"16 1\",\"pages\":\"Article 102391\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1877959X24000840/pdfft?md5=0d9739b3a6a8cb3dd6b4f91de0b76cb8&pid=1-s2.0-S1877959X24000840-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ticks and Tick-borne Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1877959X24000840\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ticks and Tick-borne Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877959X24000840","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Detection of Neoehrlichia mikurensis in 11 persons who attribute their persistent health complaints to a tick-borne disease
Background
Neoehrlichia mikurensis infections can cause symptomatic disease, particular among immunosuppressed persons. Long-lasting asymptomatic carriage of N. mikurensis may be common in endemic areas. This study explores possible associations between carriage of N. mikurensis DNA and persistent health complaints in persons who attribute their symptoms to a tick-borne disease.
Methods
Eleven persons tested positive for N. mikurensis DNA by PCR in a study cohort of 285 persons reporting persistent health complaints. The 11 persons were tested again in a follow-up sample. Oral doxycycline treatment was given if the confirmatory PCR-test was positive. Treatment response was assessed by telephone interview. Demographics, clinical manifestations, tick exposure, physical health, somatic symptom burden and fatigue were compared to persons with negative N. mikurensis PCR (controls, N = 274).
Results
Six persons had detectable N. mikurensis DNA in a follow-up sample up to 9.5 months after the index sample. Seven persons (one without a positive confirmative test) received doxycycline treatment. Three reported symptom restitution after completed antibiotic treatment. However, their symptoms were not clearly attributed to infection by N. mikurensis. We did not find any significant differences between infected persons and non-infected controls regarding their clinical manifestations and health burdens.
Conclusions
We corroborate previous evidence of long-term carriage of N. mikurensis, but cannot infer that to be causative of persistent health complaints.
期刊介绍：
Ticks and Tick-borne Diseases is an international, peer-reviewed scientific journal. It publishes original research papers, short communications, state-of-the-art mini-reviews, letters to the editor, clinical-case studies, announcements of pertinent international meetings, and editorials.
The journal covers a broad spectrum and brings together various disciplines, for example, zoology, microbiology, molecular biology, genetics, mathematical modelling, veterinary and human medicine. Multidisciplinary approaches and the use of conventional and novel methods/methodologies (in the field and in the laboratory) are crucial for deeper understanding of the natural processes and human behaviour/activities that result in human or animal diseases and in economic effects of ticks and tick-borne pathogens. Such understanding is essential for management of tick populations and tick-borne diseases in an effective and environmentally acceptable manner.
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