乙烯前体 ACCA 抑制 LPMO 以防治马铃薯晚疫病的硅学分析

IF 3.7 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of King Saud University - Science Pub Date : 2024-09-06 DOI:10.1016/j.jksus.2024.103436

Najla A. Alshaikh , Kahkashan Perveen , Sandip Debnath , Amitava Paul , Ong Ghim Hock , R.Z. Sayyed

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引用次数: 0

摘要

由病原体 Phytophthora infestans 引起的马铃薯晚疫病（PLB）严重威胁着全世界的马铃薯生产。本研究调查了乙烯前体 1-amino-cyclopropane-1-carboxylic acid（ACCA）抑制 P. infestans 中溶解多糖单氧酶（LPMOs）的潜力，溶解多糖单氧酶是参与病害发病机制的关键蛋白。我们的研究结果表明，ACCA 能显著增强马铃薯植物对 P. infestans 的免疫反应，其结合能为 -8.85 kcal/mol。将 ACCA 处理纳入现有的 PLB 管理战略，可为防治这种毁灭性病害提供一种新颖且可持续的方法。这项研究为通过创新防治措施减少马铃薯白粉病的全球影响和提高粮食安全提供了宝贵的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

In silico analysis of LPMO inhibition by ethylene precursor ACCA to combat potato late blight

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In silico analysis of LPMO inhibition by ethylene precursor ACCA to combat potato late blight

Potato late blight (PLB), caused by the pathogen Phytophthora infestans, severely threatens potato production worldwide. This study investigates the potential of the ethylene precursor 1-amino-cyclopropane-1-carboxylic acid (ACCA) to inhibit Lytic Polysaccharide Monooxygenases (LPMOs) in P. infestans, a key protein involved in the disease’s pathogenesis. Our findings demonstrate that ACCA significantly enhances the immune response in potato plants against P. infestans, with a binding energy of −8.85 kcal/mol. Integrating ACCA treatment into existing PLB management strategies could offer a novel and sustainable approach to combat this devastating disease. This research provides valuable insights into reducing the global impact of PLB and improving food security through innovative control measures.

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来源期刊

Journal of King Saud University - Science Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

2.60%

发文量

642

审稿时长

49 days

期刊介绍： Journal of King Saud University – Science is an official refereed publication of King Saud University and the publishing services is provided by Elsevier. It publishes peer-reviewed research articles in the fields of physics, astronomy, mathematics, statistics, chemistry, biochemistry, earth sciences, life and environmental sciences on the basis of scientific originality and interdisciplinary interest. It is devoted primarily to research papers but short communications, reviews and book reviews are also included. The editorial board and associated editors, composed of prominent scientists from around the world, are representative of the disciplines covered by the journal.