抗菌、抗癌和基因编辑疗法的新方向

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-08-22 DOI:10.1021/acsmedchemlett.4c0040510.1021/acsmedchemlett.4c00405

Robert B. Kargbo*,

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引用次数: 0

摘要

制药和基因治疗研究的最新进展推动了新型化合物和给药系统的开发，这些化合物和给药系统针对的是尚未满足医疗需求的关键领域，包括耐药细菌感染、癌症和遗传疾病。本专利摘要回顾了三项最新专利的主要发现，这些专利描述了三环喹诺酮化合物和用于基因编辑的腺相关病毒 (AAV) 载体的创新。这些创新表明，在治疗抗生素耐药细菌感染、BCL6 依赖性癌症以及有效传递基于 CRISPR 的基因编辑工具方面取得了重大进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

New Directions in Antibacterial, Anticancer, and Gene Editing Therapies

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New Directions in Antibacterial, Anticancer, and Gene Editing Therapies

Recent advancements in pharmaceutical and gene therapy research have led to the development of novel compounds and delivery systems that target critical areas of unmet medical needs, including drug-resistant bacterial infections, cancer, and genetic diseases. This Patent Highlight reviews the key findings from three recent patents that describe innovations in tricyclic quinolone compounds and adeno-associated virus (AAV) vectors for gene editing. These innovations demonstrate significant progress in the treatment of antibiotic-resistant bacterial infections, BCL6-dependent cancers, and the efficient delivery of CRISPR-based gene editing tools.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.