简单快速的光学旋转色散和圆二色性同步测量策略

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-09-11 DOI:10.1038/s41377-024-01595-y

Junjie Du

引用次数: 0

摘要

一种基于腔体的简单技术能够在几毫秒内同时测量光学旋转色散和圆二色性，具有超高的灵敏度和前所未有的光谱分辨率。这一进步为包括药物开发、临床诊断以及食品科学与安全在内的各种生化应用带来了巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A simple and rapid simultaneous measurement strategy for optical rotatory dispersion and circular dichroism

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A simple and rapid simultaneous measurement strategy for optical rotatory dispersion and circular dichroism

A simple cavity-based technology capable of simultaneously measuring optical rotary dispersion and circular dichroism within milliseconds offers ultra-high sensitivity and unprecedented spectral resolution. This advancement holds significant potential for various biochemical applications, including drug development, clinical diagnosis, and food science and safety.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.