用于闭环经颅超声神经刺激的形状变形皮质粘合传感器

IF 33.7 1区工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

Nature Electronics Pub Date : 2024-09-11 DOI:10.1038/s41928-024-01240-x

Sungjun Lee, Jeungeun Kum, Sumin Kim, Hyunjin Jung, Soojung An, Soon Jin Choi, Jae Hyuk Choi, Jinseok Kim, Ki Jun Yu, Wonhye Lee, Hyeok Kim, Hyung-Seop Han, Mikyung Shin, Hyungmin Kim, Donghee Son

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引用次数: 0

摘要

经颅聚焦超声因其空间分辨率和深度穿透性，对耐药性癫痫具有良好的非侵入性治疗效果。然而，由于缺乏对超声波不敏感的闭环神经刺激设备，目前使用固定神经刺激方案的人工策略无法提供针对患者的精确治疗。在此，我们报告了一种用于闭环经颅超声神经刺激的形状变形皮质粘附传感器。该传感器由儿茶酚共轭藻酸盐水凝胶粘合剂、可拉伸的 16 通道电极阵列和粘性自愈合聚合物基底组成，并与脉冲控制经颅聚焦超声装置耦合。它能为弯曲的皮质表面提供保形和稳固的固定，我们还证明了它能在清醒的癫痫啮齿动物经颅聚焦超声神经刺激过程中记录稳定的神经信号。它的传感性能允许实时检测具有意外和不规则高频振荡的癫痫发作前信号，我们还展示了在清醒啮齿动物的超声刺激下，由完整皮质活动监督的闭环癫痫发作控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation

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A shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation

Transcranial focused ultrasound has shown promising non-invasive therapeutic effects for drug-resistant epilepsy due to its spatial resolution and depth penetrability. However, current manual strategies, which use fixed neurostimulation protocols, cannot provide precise patient-specific treatment due to the absence of ultrasound wave-insensitive closed-loop neurostimulation devices. Here, we report a shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation. The sensor consists of a catechol-conjugated alginate hydrogel adhesive, a stretchable 16-channel electrode array and a viscoplastic self-healing polymeric substrate, and is coupled to a pulse-controlled transcranial focused ultrasound device. It can provide conformal and robust fixation to curvy cortical surfaces, and we show that it is capable of stable neural signal recording in awake seizure rodents during transcranial focused ultrasound neurostimulation. The sensing performance allows real-time detection of preseizure signals with unexpected and irregular high-frequency oscillations, and we demonstrate closed-loop seizure control supervised by intact cortical activity under ultrasound stimulation in awake rodents. A sensor that consists of a catechol-conjugated alginate hydrogel adhesive, a stretchable 16-channel electrode array and a viscoplastic self-healing polymeric substrate, and is coupled to a pulse-controlled transcranial focused ultrasound device, can be used for closed-loop transcranial ultrasound neurostimulation.

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来源期刊

Nature Electronics Engineering-Electrical and Electronic Engineering

CiteScore

47.50

自引率

2.30%

发文量

159

期刊介绍： Nature Electronics is a comprehensive journal that publishes both fundamental and applied research in the field of electronics. It encompasses a wide range of topics, including the study of new phenomena and devices, the design and construction of electronic circuits, and the practical applications of electronics. In addition, the journal explores the commercial and industrial aspects of electronics research. The primary focus of Nature Electronics is on the development of technology and its potential impact on society. The journal incorporates the contributions of scientists, engineers, and industry professionals, offering a platform for their research findings. Moreover, Nature Electronics provides insightful commentary, thorough reviews, and analysis of the key issues that shape the field, as well as the technologies that are reshaping society. Like all journals within the prestigious Nature brand, Nature Electronics upholds the highest standards of quality. It maintains a dedicated team of professional editors and follows a fair and rigorous peer-review process. The journal also ensures impeccable copy-editing and production, enabling swift publication. Additionally, Nature Electronics prides itself on its editorial independence, ensuring unbiased and impartial reporting. In summary, Nature Electronics is a leading journal that publishes cutting-edge research in electronics. With its multidisciplinary approach and commitment to excellence, the journal serves as a valuable resource for scientists, engineers, and industry professionals seeking to stay at the forefront of advancements in the field.