白花蛇舌草种子中的含氮化合物

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-09-10 DOI:10.1016/j.phytol.2024.08.009

Xue Liu , Degang Kong , Liang Ding , Honglei Zhou

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引用次数: 0

摘要

对白花蛇舌草的干燥成熟种子进行了研究。从白花蛇舌草种子中分离出两种未曾描述过的含氮化合物：3-(4′-羟基苄氧基)戊-4-烯腈（1）、N，N-双[(4-羟基苯基)甲基]氨基甲酸乙酯（2），以及两种新的天然产物：N-(4-羟基苄基)氨基甲酸乙酯（3）、4-羟基-N-(4-羟基苯基)苯乙酰胺（4）。通过核磁共振和 HR-ESI-MS 分析阐明了这四种化合物的结构。利用 CuSO4 诱导的斑马鱼炎症模型对化合物 1、2 和 4 的抗炎活性进行了筛选，结果表明化合物 1、2 和 4 具有明显的抗炎活性。

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Nitrogenous compounds from the Seeds of Sinapis alba

The dried and mature seeds of Sinapis alba were investigated. Two undescribed nitrogenous compounds, 3-(4′-hydroxybenzyloxy) pent-4-enenitrile (1), N, N-bis[(4-hydroxyphenyl)methyl] ethyl carbamate (2), together with two new natural products, N-(4-hydroxybenzyl) ethyl carbamate (3), 4-hydroxy-N-(4-hydroxyphenyl)benzeneacetamide (4), were isolated from the Seeds of Sinapis alba. The structures of the four compounds were elucidated by NMR and HR-ESI–MS analyses. The anti-inflammatory activity of compounds 1, 2, and 4 was screened using the zebrafish inflammation model induced by CuSO₄, which showed that compounds 1, 2, and 4 had obvious anti-inflammatory activity.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.