小胶质细胞桥接大脑活动和血压

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-09-10 DOI:10.1016/j.immuni.2024.08.006

Yanxia Rao, Bo Peng

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引用次数: 0

摘要

我们的大脑并不是一个与外周系统隔绝的免疫孤岛，但人们对非神经元脑细胞如何与外周系统相互作用还不甚了解。Wei 等人报告说，下丘脑室旁核（PVN）中的小胶质细胞具有独特的血管，能检测到血液动力学紊乱产生的 ATP。PVN 中的这些小胶质细胞通过 ATP-P2Y12-C/EBPβ 信号调节对高血压的反应。

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Microglia bridge brain activity and blood pressure

Our brain is not an immune-privileged island isolated from peripheries, but how non-neuronal brain cells interact with the peripheral system is not well understood. Wei et al. report that microglia in the hypothalamic paraventricular nucleus (PVN) with unique vasculature can detect ATP derived from hemodynamic disturbance. These microglia in the PVN regulate the response to hypertension via ATP-P2Y12-C/EBPβ signaling.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.