多纤毛上皮细胞:成人大脑生物学和病理学的最新进展

IF 9.3 1区 医学 Q1 CLINICAL NEUROLOGY
Adam M. R. Groh, Yeji Lori Song, Fiona Tea, Brianna Lu, Stephanie Huynh, Elia Afanasiev, Maxime Bigotte, Marc R. Del Bigio, Jo Jo Anne Stratton
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引用次数: 0

摘要

成熟的多纤毛上皮细胞排列在脑室中,它们在脑脊液(CSF)和脑实质之间形成部分屏障,并通过协调的纤毛跳动调节局部 CSF 微循环。尽管外膜是一个高度特化的脑界面,具有屏障、营养甚至再生能力,但它在神经胶质生物学中仍然是一个不合适的部分。我们对 2010 年后的成熟多纤毛外膜细胞文献进行了范围界定,对该领域的开创性评论进行了更新。我们描述了近期的研究结果是如何质疑或证实上皮细胞的经典观点的。除了综述之外,我们还记录了自1980年以来用于描述多纤毛上皮细胞的基本方法和研究特点。我们的综述为今后研究成熟的多纤毛上皮细胞提供了全面的资料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multiciliated ependymal cells: an update on biology and pathology in the adult brain

Multiciliated ependymal cells: an update on biology and pathology in the adult brain

Multiciliated ependymal cells: an update on biology and pathology in the adult brain

Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF microcirculation through coordinated ciliary beating. Although the ependyma is a highly specialized brain interface with barrier, trophic, and perhaps even regenerative capacity, it remains a misfit in the canon of glial neurobiology. We provide an update to seminal reviews in the field by conducting a scoping review of the post-2010 mature multiciliated ependymal cell literature. We delineate how recent findings have either called into question or substantiated classical views of the ependymal cell. Beyond this synthesis, we document the basic methodologies and study characteristics used to describe multiciliated ependymal cells since 1980. Our review serves as a comprehensive resource for future investigations of mature multiciliated ependymal cells.

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来源期刊
Acta Neuropathologica
Acta Neuropathologica 医学-病理学
CiteScore
23.70
自引率
3.90%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Acta Neuropathologica publishes top-quality papers on the pathology of neurological diseases and experimental studies on molecular and cellular mechanisms using in vitro and in vivo models, ideally validated by analysis of human tissues. The journal accepts Original Papers, Review Articles, Case Reports, and Scientific Correspondence (Letters). Manuscripts must adhere to ethical standards, including review by appropriate ethics committees for human studies and compliance with principles of laboratory animal care for animal experiments. Failure to comply may result in rejection of the manuscript, and authors are responsible for ensuring accuracy and adherence to these requirements.
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