Rui Wang, Ni-sha Wu, Li Wang, Zhi-zhao Zhang, Cheng-fang Wang, Yan Wang, Yan Liang, Yi Zhang, Xiao-wei Qi
{"title":"对人类癌症中 Wnt 家族成员 7B 的泛癌症分析","authors":"Rui Wang, Ni-sha Wu, Li Wang, Zhi-zhao Zhang, Cheng-fang Wang, Yan Wang, Yan Liang, Yi Zhang, Xiao-wei Qi","doi":"10.1002/cai2.139","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Previous studies have highlighted the crucial role of <i>Wnt7B</i> in the development of various cancers, including breast, pancreatic, and gastric cancers. However, research into the involvement of <i>Wnt7B</i> is often confined to specific tumor types, with a noticeable lack of comprehensive studies spanning multiple cancer forms. The potential of <i>Wnt7B</i> as a diagnostic or prognostic cancer biomarker has not been fully explored.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this study, we combined bioinformatics and immunohistochemistry analyses to examine the expression patterns and functions of <i>Wnt7B</i> in cancerous and adjacent noncancerous tissues across a range of tumors.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Our data indicate that <i>Wnt7B</i> may serve as a novel prognostic biomarker and therapeutic target in certain cancers.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>We found significant upregulation of <i>Wnt7B</i> expression levels in the majority of cancer cases examined. Furthermore, <i>Wnt7B</i> can influence cancer prognosis by modulating the tumor microenvironment, immune cell infiltration, and tumor stemness, among other factors. Additionally, we examined the associations between anticancer drug sensitivity and <i>Wnt7B</i> expression, which could aid in the development of more precise clinical therapies.</p>\n </section>\n </div>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"3 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.139","citationCount":"0","resultStr":"{\"title\":\"A pan-cancer analysis of Wnt family member 7B in human cancers\",\"authors\":\"Rui Wang, Ni-sha Wu, Li Wang, Zhi-zhao Zhang, Cheng-fang Wang, Yan Wang, Yan Liang, Yi Zhang, Xiao-wei Qi\",\"doi\":\"10.1002/cai2.139\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Previous studies have highlighted the crucial role of <i>Wnt7B</i> in the development of various cancers, including breast, pancreatic, and gastric cancers. However, research into the involvement of <i>Wnt7B</i> is often confined to specific tumor types, with a noticeable lack of comprehensive studies spanning multiple cancer forms. The potential of <i>Wnt7B</i> as a diagnostic or prognostic cancer biomarker has not been fully explored.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In this study, we combined bioinformatics and immunohistochemistry analyses to examine the expression patterns and functions of <i>Wnt7B</i> in cancerous and adjacent noncancerous tissues across a range of tumors.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Our data indicate that <i>Wnt7B</i> may serve as a novel prognostic biomarker and therapeutic target in certain cancers.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>We found significant upregulation of <i>Wnt7B</i> expression levels in the majority of cancer cases examined. Furthermore, <i>Wnt7B</i> can influence cancer prognosis by modulating the tumor microenvironment, immune cell infiltration, and tumor stemness, among other factors. Additionally, we examined the associations between anticancer drug sensitivity and <i>Wnt7B</i> expression, which could aid in the development of more precise clinical therapies.</p>\\n </section>\\n </div>\",\"PeriodicalId\":100212,\"journal\":{\"name\":\"Cancer Innovation\",\"volume\":\"3 5\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.139\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Innovation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cai2.139\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Innovation","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cai2.139","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A pan-cancer analysis of Wnt family member 7B in human cancers
Background
Previous studies have highlighted the crucial role of Wnt7B in the development of various cancers, including breast, pancreatic, and gastric cancers. However, research into the involvement of Wnt7B is often confined to specific tumor types, with a noticeable lack of comprehensive studies spanning multiple cancer forms. The potential of Wnt7B as a diagnostic or prognostic cancer biomarker has not been fully explored.
Methods
In this study, we combined bioinformatics and immunohistochemistry analyses to examine the expression patterns and functions of Wnt7B in cancerous and adjacent noncancerous tissues across a range of tumors.
Results
Our data indicate that Wnt7B may serve as a novel prognostic biomarker and therapeutic target in certain cancers.
Conclusion
We found significant upregulation of Wnt7B expression levels in the majority of cancer cases examined. Furthermore, Wnt7B can influence cancer prognosis by modulating the tumor microenvironment, immune cell infiltration, and tumor stemness, among other factors. Additionally, we examined the associations between anticancer drug sensitivity and Wnt7B expression, which could aid in the development of more precise clinical therapies.