Niken Larasati, Satibi Satibi, Susi Ari Kristina, Lutfan Lazuardi
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Clinical pharmacists reviewed electronic health data to examine DRPs. The Fisher's exact test evaluated the association between DRPs and LoS.</p><p><strong>Results: </strong>A total of 60.7% (<i>n</i> = 17) of the participants were females, with the majority falling into the age group ≥ 65 years old (<i>n</i> = 11, 29.7%). A significant portion experienced LoS > 7 days (<i>n</i> = 17, 60.7%). Antidiabetic monotherapy was predominant, and the categories of DRPs included adverse drug reaction (<i>n =</i> 15, 40.5%), dosage too high (<i>n</i> = 6, 16.2%), wrong drug (<i>n</i> = 6, 16.2%), non-adherence (<i>n</i> = 4, 10.8%), need for additional therapy (<i>n =</i> 4, 10.8%) and dosage too low (<i>n =</i> 2, 5.4%). A significant association was observed between non-adherence and LoS (<i>P =</i> 0.016). The possibility of experiencing LoS of 1-7 days increased by 3.43 times with improved non-adherence (OR = 3.43; 95% CI: 1.83, 6.39). In this context, non-adherence refers to DRPs associated with the non-compliance of patients with the prescribed treatment plan.</p><p><strong>Conclusion: </strong>This study concludes that non-adherence was significantly associated with hospital LoS.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 4","pages":"162-173"},"PeriodicalIF":1.1000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377014/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Association between Drug-Related Problems and Length of Stay of Type 2 Diabetes Mellitus Patients.\",\"authors\":\"Niken Larasati, Satibi Satibi, Susi Ari Kristina, Lutfan Lazuardi\",\"doi\":\"10.21315/mjms2024.31.4.13\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Drug-related problems (DRPs) are treatment-related occurrences that affect therapeutic efficacy. In a previous study, approximately 279 out of 330 (84.5%) patients with type 2 diabetes mellitus (T2DM) had experienced at least one DRP, including non-optimal drug effects (<i>n</i> = 240, 52.7%) and indications without medication (<i>n =</i> 137, 30.1%). Patients who were hospitalised for 5-10 days had the highest number of DRPs. Therefore, this study investigates the association between DRPs and length of stay (LoS) in patients with T2DM.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from January 2020 to May 2023 at Rumah Sakit Akademik, Universitas Gadjah Mada, Yogyakarta, Indonesia. Clinical pharmacists reviewed electronic health data to examine DRPs. The Fisher's exact test evaluated the association between DRPs and LoS.</p><p><strong>Results: </strong>A total of 60.7% (<i>n</i> = 17) of the participants were females, with the majority falling into the age group ≥ 65 years old (<i>n</i> = 11, 29.7%). A significant portion experienced LoS > 7 days (<i>n</i> = 17, 60.7%). Antidiabetic monotherapy was predominant, and the categories of DRPs included adverse drug reaction (<i>n =</i> 15, 40.5%), dosage too high (<i>n</i> = 6, 16.2%), wrong drug (<i>n</i> = 6, 16.2%), non-adherence (<i>n</i> = 4, 10.8%), need for additional therapy (<i>n =</i> 4, 10.8%) and dosage too low (<i>n =</i> 2, 5.4%). A significant association was observed between non-adherence and LoS (<i>P =</i> 0.016). The possibility of experiencing LoS of 1-7 days increased by 3.43 times with improved non-adherence (OR = 3.43; 95% CI: 1.83, 6.39). 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引用次数: 0
摘要
导言：药物相关问题（DRPs）是与治疗相关的、影响疗效的现象。在之前的一项研究中，330 名 2 型糖尿病（T2DM）患者中约有 279 人（84.5%）至少经历过一次药物相关问题，包括非最佳药物效果（240 人，52.7%）和无药物适应症（137 人，30.1%）。住院 5-10 天的患者发生 DRP 的次数最多。因此，本研究调查了 DRP 与 T2DM 患者住院时间（LoS）之间的关系：这项横断面研究于 2020 年 1 月至 2023 年 5 月在印度尼西亚日惹加札马达大学 Rumah Sakit Akademik 学院进行。临床药剂师审查了电子健康数据，以检查 DRP。费雪精确检验评估了DRP与LoS之间的关联：共有 60.7% 的参与者（n = 17）为女性，其中大多数人的年龄≥ 65 岁（n = 11，29.7%）。相当一部分人的 LoS 超过 7 天（17 人，占 60.7%）。抗糖尿病单药治疗占主导地位，DRPs类别包括药物不良反应（15例，40.5%）、剂量过高（6例，16.2%）、用错药（6例，16.2%）、不依从（4例，10.8%）、需要额外治疗（4例，10.8%）和剂量过低（2例，5.4%）。未坚持治疗与 LoS 之间存在明显关联（P = 0.016）。随着不依从性的改善，出现 1-7 天 LoS 的可能性增加了 3.43 倍（OR = 3.43；95% CI：1.83, 6.39）。在这种情况下，不依从性指的是与患者不遵从处方治疗计划有关的 DRP：本研究得出结论，不依从性与医院 LoS 显著相关。
The Association between Drug-Related Problems and Length of Stay of Type 2 Diabetes Mellitus Patients.
Introduction: Drug-related problems (DRPs) are treatment-related occurrences that affect therapeutic efficacy. In a previous study, approximately 279 out of 330 (84.5%) patients with type 2 diabetes mellitus (T2DM) had experienced at least one DRP, including non-optimal drug effects (n = 240, 52.7%) and indications without medication (n = 137, 30.1%). Patients who were hospitalised for 5-10 days had the highest number of DRPs. Therefore, this study investigates the association between DRPs and length of stay (LoS) in patients with T2DM.
Methods: A cross-sectional study was conducted from January 2020 to May 2023 at Rumah Sakit Akademik, Universitas Gadjah Mada, Yogyakarta, Indonesia. Clinical pharmacists reviewed electronic health data to examine DRPs. The Fisher's exact test evaluated the association between DRPs and LoS.
Results: A total of 60.7% (n = 17) of the participants were females, with the majority falling into the age group ≥ 65 years old (n = 11, 29.7%). A significant portion experienced LoS > 7 days (n = 17, 60.7%). Antidiabetic monotherapy was predominant, and the categories of DRPs included adverse drug reaction (n = 15, 40.5%), dosage too high (n = 6, 16.2%), wrong drug (n = 6, 16.2%), non-adherence (n = 4, 10.8%), need for additional therapy (n = 4, 10.8%) and dosage too low (n = 2, 5.4%). A significant association was observed between non-adherence and LoS (P = 0.016). The possibility of experiencing LoS of 1-7 days increased by 3.43 times with improved non-adherence (OR = 3.43; 95% CI: 1.83, 6.39). In this context, non-adherence refers to DRPs associated with the non-compliance of patients with the prescribed treatment plan.
Conclusion: This study concludes that non-adherence was significantly associated with hospital LoS.
期刊介绍：
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access, fully online journal that is published at least six times a year. The journal’s scope encompasses all aspects of medical sciences including biomedical, allied health, clinical and social sciences. We accept high quality papers from basic to translational research especially from low & middle income countries, as classified by the United Nations & World Bank (https://datahelpdesk.worldbank.org/knowledgebase/ articles/906519), with the aim that published research will benefit back the bottom billion population from these countries. Manuscripts submitted from developed or high income countries to MJMS must contain data and information that will benefit the socio-health and bio-medical sciences of these low and middle income countries. The MJMS editorial board consists of internationally regarded clinicians and scientists from low and middle income countries.
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