作为 COVID-19 炎症途径调节剂的植物成分:全面回顾与建议。

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Pragati Gupta, Kamal Dev, Gurjot Kaur
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引用次数: 0

摘要

SARS-CoV-2 感染会导致炎症通路紊乱,这从根本上促进了 COVID-19 的病理生理学。本综述批判性地评估了科学文献中的空白,并介绍了 COVID-19 炎症信号通路的现状。我们提出,植物成分可用于治疗与 COVID-19 相关的炎症,其中有几种已在传统药物中配制。为此,我们在 PubMed 数据库中进行了广泛的文献分析,以收集相关的体外、体内和人类患者研究,这些研究表明 COVID-19 中的炎症通路被上调。同时,还筛选了与炎症或 COVID-19 相关炎症的已知细胞机制有关的植物成分的科学文献。对于自噬和有丝分裂的细胞通路证据不足的研究,被认为不在研究范围内,并排除在研究之外。最终分析结果以图表形式呈现,并对其准确性进行了评估。我们的研究结果表明,转录因子 NF-κB 经常参与与 COVID-19 相关的炎症信号通路。此外,MAPK 信号通路也与炎症分子的产生有关。此外,研究还分析了具有黄酮和酚类骨架的植物成分可以抑制 TLR4 受体或其连续的信号分子,从而降低 NF-κB 的活性,抑制细胞因子的产生。虽然对抗疗法可以治疗 COVID-19 的早期阶段,但抗炎植物成分和现有的阿育吠陀配方可能会作用于 COVID-19 相关的炎症通路,并提供额外的治疗策略。因此,我们建议使用类黄酮和酚类植物成分来治疗与 COVID-19 感染相关的炎症以及类似的病毒性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phytoconstituents as modulator of inflammatory pathways for COVID-19: A comprehensive review and recommendations.

SARS-CoV-2 infection causes disruptions in inflammatory pathways, which fundamentally contribute to COVID-19 pathophysiology. The present review critically evaluates the gaps in scientific literature and presents the current status regarding the inflammatory signaling pathways in COVID-19. We propose that phytoconstituents can be used to treat COVID-19 associated inflammation, several already formulated in traditional medications. For this purpose, extensive literature analysis was conducted in the PubMed database to collect relevant in vitro, in vivo, and human patient studies where inflammation pathways were shown to be upregulated in COVID-19. Parallelly, scientific literature was screened for phytoconstituents with known cellular mechanisms implicated for inflammation or COVID-19 associated inflammation. Studies with insufficient evidence on cellular pathways for autophagy and mitophagy were considered out of scope and excluded from the study. The final analysis was visualized in figures and evaluated for accuracy. Our findings demonstrate the frequent participation of NF-κB, a transcription factor, in inflammatory signaling pathways linked to COVID-19. Moreover, the MAPK signaling pathway is also implicated in producing inflammatory molecules. Furthermore, it was also analyzed that the phytoconstituents with flavonoid and phenolic backbones could inhibit either the TLR4 receptor or its consecutive signaling molecules, thereby, decreasing NF-κB activity and suppressing cytokine production. Although, allopathy has treated the early phase of COVID-19, anti-inflammatory phytoconstituents and existing ayurvedic formulations may act on the COVID-19 associated inflammatory pathways and provide an additional treatment strategy. Therefore, we recommend the usage of flavonoids and phenolic phytoconstituents for the treatment of inflammation associated with COVID-19 infection and similar viral ailments.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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