一名患有全身性幼年特发性关节炎和肾病综合征的儿童。

IF 2.6 3区医学 Q1 PEDIATRICS

Pediatric Nephrology Pub Date : 2025-02-01 Epub Date: 2024-09-09 DOI:10.1007/s00467-024-06495-2

Jyoti S Singhal, Nivedita Pande, Jyoti Sharma

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引用次数: 0

摘要

导言：肾脏淀粉样变性是幼年特发性关节炎（JIA）患儿的一种罕见并发症，更常见于全身性发病的幼年特发性关节炎（SOJIA）。它通常表现为无症状性蛋白尿：病例报告：一名 11.5 岁的男孩在 6 岁时患上了全身性幼年特发性关节炎，他因肛门瘙痒来我院就诊。尿液分析和血清白蛋白提示诊断为肾病综合征（NS），肾活检证实有淀粉样变性沉积。开始使用注射用托珠单抗进行治疗。蛋白尿已经减少，肾功能正常：结论：患 SOJIA 的儿童应监测蛋白尿，以便及时为他们提供适当的治疗。

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A child with systemic onset juvenile idiopathic arthritis and nephrotic syndrome.

Introduction: Amyloidosis of the kidney is a rare complication in children with juvenile idiopathic arthritis (JIA), more commonly seen with systemic onset juvenile idiopathic arthritis (SOJIA). It usually presents with asymptomatic proteinuria.

Case report: An 11.5-year-old boy with onset of SOJIA at 6 years of age came to our clinic with anasarca. Urinalysis and serum albumin suggested a diagnosis of nephrotic syndrome (NS) and kidney biopsy confirmed amyloidosis deposits. Treatment with injection tocilizumab was initiated. The proteinuria has decreased, and kidney functions are normal.

Conclusion: Children with SOJIA should be monitored for proteinuria so that they can be offered timely appropriate therapy.

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.