改变光-暗周期对加速 NOD 小鼠 1 型糖尿病的影响

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S465917

Amjaad Muhammad Ar Reshaid, Yasser Abdulathim Alshawakir, Mohammed A Almuayrifi, Omar Salem Al-Attas, Ahmed S BaHammam, Reem Abdullah Al Khalifah

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引用次数: 0

摘要

目的我们的目的是评估光暗周期改变和饮用软饮料对非肥胖糖尿病（NOD）小鼠模型中1型糖尿病（T1DM）加速发展的影响：方法：我们让雌性 NOD 和 C57BL/6 小鼠从 5 周龄开始饮用广告软饮料和/或改变 T20 光暗周期，直到出现糖尿病或小鼠长到 30 周龄。每组 7-15 只小鼠。我们每周监测体重、体长、血糖水平和胰岛素自身抗体（IAA）水平：结果：在75只NOD小鼠和22只C57BL/6小鼠中，41只NOD小鼠罹患糖尿病，6只小鼠在7至8周龄期间死亡。NOD 对照组小鼠发生 T1DM 的平均时间为 20 周。受光暗周期改变影响的 NOD 小鼠发生 T1DM 的时间提前了两周，危险比为 2.65，95th CI (0.70, 10.04) p = 0.15。）结论：光-暗周期改变对NOD小鼠的危害比为2.65，95th CI (0.70, 10.04) p = 0.15：结论：受光暗周期改变影响的 NOD 小鼠有提前出现 T1DM 的趋势，但这种差异在统计学上并不显著。还需要进一步研究，利用更大的样本量和不同的动物物种来证实我们的发现。

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The Impact of Light-Dark Cycle Alteration on the Acceleration of Type 1 Diabetes in NOD Mice Model.

Objective: We aimed to evaluate the effect of light-dark cycle alteration and soft drink consumption on the acceleration of type 1 diabetes mellitus (T1DM) development among non-obese diabetic (NOD) mice model.

Methods: We exposed female NOD and C57BL/6 mice from the age of 5 weeks to either adlib soft drink consumption and/or T20 light-dark cycle alteration until the development of diabetes, or the mice reached the age of 30 weeks. Each group consisted of 7-15 mice. We monitored weight, length, blood glucose level, and insulin autoantibody (IAA) levels weekly.

Results: Out of 75 NOD and 22 C57BL/6 mice, 41 NOD mice developed diabetes, and 6 mice died between 7 and 8 weeks of age. The mean time to development of T1DM among NOD control mice was 20 weeks. The time to development of T1DM was accelerated by two weeks in the NOD mice exposed to light-dark cycle alteration, hazard ratio of 2.65,95th CI (0.70, 10.04) p = 0.15). The other groups developed T1DM, similar to the control group.

Conclusion: There was a trend toward earlier development of T1DM among NOD mice exposed to light-dark cycle alteration, but this difference was not statistically significant. Further studies are needed to confirm our findings using larger sample sizes and different animal species.

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.