S100A12 可抑制肺炎链球菌，并有助于角膜上皮细胞的体外和体内伤口愈合。

IF 2.6 4区医学 Q3 IMMUNOLOGY

Microbes and Infection Pub Date : 2024-09-07 DOI:10.1016/j.micinf.2024.105421

Priyasha Mishra, Sanjay Ch, Abhijit Ghosh, Srijita Kundu, Riddhi Agarwal, Bharathi Bhogapurapu, Swati Biswas, Sanhita Roy

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引用次数: 0

摘要

肺炎链球菌是全球角膜感染的主要病因，尽管对抗生素敏感，但其攻击性极强，而且对抗生素的耐药性也在增强。抗菌肽通常被认为是对抗抗生素耐药性的有效替代品，我们在此研究了宿主防御肽 S100A12 在伤口愈合和肺炎链球菌感染中可能发挥的作用。S100A12 通过破坏膜完整性和增加活性氧的生成，明显抑制了肺炎双球菌的生长。此外，S100A12 还能通过激活表皮生长因子受体和 MAPK 信号通路，加速人角膜上皮细胞和小鼠角膜伤口模型的细胞迁移和伤口闭合。

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S100A12 inhibits Streptococcus pneumoniae and aids in wound healing of corneal epithelial cells both in vitro and in vivo.

Streptococcus pneumoniae, a leading cause of corneal infections worldwide, are extremely aggressive despite antibiotic sensitivity and exhibit increased resistance towards antibiotics. Antimicrobial peptides are often considered as potent alternatives against antibiotic resistance and here we have investigated the possible roles of S100A12, a host defense peptide, in wound healing and S. pneumoniae infection. S100A12 significantly inhibited growth of S. pneumoniae by disruption of membrane integrity along with increased generation of reactive oxygen species. Additionally, S100A12 accelerated cell migration and wound closure in human corneal epithelial cells and in a murine corneal wound model by activation of EGFR and MAPK signaling pathways.

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来源期刊

Microbes and Infection 医学-病毒学

CiteScore

12.60

自引率

1.70%

发文量

审稿时长

40 days

期刊介绍： Microbes and Infection publishes 10 peer-reviewed issues per year in all fields of infection and immunity, covering the different levels of host-microbe interactions, and in particular: the molecular biology and cell biology of the crosstalk between hosts (human and model organisms) and microbes (viruses, bacteria, parasites and fungi), including molecular virulence and evasion mechanisms. the immune response to infection, including pathogenesis and host susceptibility. emerging human infectious diseases. systems immunology. molecular epidemiology/genetics of host pathogen interactions. microbiota and host "interactions". vaccine development, including novel strategies and adjuvants. Clinical studies, accounts of clinical trials and biomarker studies in infectious diseases are within the scope of the journal. Microbes and Infection publishes articles on human pathogens or pathogens of model systems. However, articles on other microbes can be published if they contribute to our understanding of basic mechanisms of host-pathogen interactions. Purely descriptive and preliminary studies are discouraged.