在卵巢刺激过程中使用人绝经促性腺激素补充促黄体生成素与小剂量人绒毛膜促性腺激素相比,不会影响新鲜和冷冻胚胎移植后的活产率。

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Linnea Fischer, Rebecca K. Chung, Sung Tae Kim, Rebecca Flyckt, Rachel Weinerman
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引用次数: 0

摘要

目的:促黄体生成素(LH)在卵泡成熟过程中发挥着重要作用。人绝经期促性腺激素(hMG)或小剂量人绒毛膜促性腺激素(hCG)可在体外受精(IVF)卵巢刺激期间提供 LH 补充,但直接比较它们对 IVF 结果影响的研究有限。本研究旨在确定在体外受精卵巢刺激过程中使用 hMG 补充 LH 与使用低剂量 hCG 是否会影响活产率:纳入本学术中心2017年至2021年在标准长效或拮抗剂方案后,在刺激周期中补充hMG(75-250 IU)或低剂量hCG(50-100 IU)的新鲜和冷冻胚胎移植(ET)。统计分析采用 T 检验、曼-惠特尼 U 检验、卡方检验、多元线性回归和逻辑回归:结果:共分析了 468 个不同的刺激周期,其中新鲜胚胎移植 213 例,冷冻胚胎移植 412 例。hMG 与低剂量 hCG 的成熟卵母细胞产量较低(10.9 对 11.8,p = 0.044),但优质囊胚产量相似(3.6 对 3.9,p = 0.11)。新鲜胚胎移植(42% 对 49%,p = 0.24)和冷冻胚胎移植(46% 对 53%,p = 0.45)的活产率相当。多重逻辑回归结果显示,在新鲜胚胎移植和冷冻胚胎移植中,补充促性腺激素与活产之间没有关联:结论:补充 hMG 和小剂量 hCG 后,新鲜和冷冻 IVF-ET 的妊娠结果相当,这表明补充 LH 的剂量方案具有灵活性,可以解决患者或医生的偏好或成本问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Luteinizing hormone supplementation with human menopausal gonadotropin versus low dose human chorionic gonadotropin during ovarian stimulation does not affect live birth rates after fresh and frozen embryo transfer

Aim

Luteinizing hormone (LH) plays an important role in ovarian follicle maturation. Human menopausal gonadotropin (hMG) or low dose human chorionic gonadotropin (hCG) can provide LH supplementation during in vitro fertilization (IVF) ovarian stimulation, though studies directly comparing their impact on IVF outcomes are limited. The aim of the study was to determine whether LH supplementation with hMG versus low dose hCG during IVF stimulation affects live birth rate.

Methods

Fresh and frozen embryo transfers (ET) from 2017 to 2021 after standard long or antagonist protocols supplemented with hMG (75–250 IU) or low dose hCG (50–100 IU) during stimulation cycles in our academic center were included. Statistical analysis was performed with T-tests, Mann–Whitney U tests, Chi-square, and multiple linear and logistic regression.

Results

Four hundred and sixty eight unique stimulation cycles resulting in 213 fresh and 412 frozen embryo transfers were analyzed. There was a lower mature oocyte yield (10.9 vs. 11.8, p = 0.044) but similar high-quality blastocyst yield (3.6 vs. 3.9, p = 0.11) for hMG vs low dose hCG. Live birth rates per transfer were comparable for fresh (42% vs. 49%, p = 0.24) and frozen (46% vs. 53%, p = 0.45) embryo transfers. Multiple logistic regressions showed no association between supplemental gonadotropin and live birth for both fresh and frozen embryo transfers.

Conclusion

Fresh and frozen IVF-ET pregnancy outcomes were comparable after hMG versus low dose hCG supplementation, suggesting flexibility in supplemental LH dosing regimens that may address patient or physician preference or cost concerns.

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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
376
审稿时长
3-6 weeks
期刊介绍: The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
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