{"title":"甲状腺功能与子痫前期:双样本双向孟德尔随机研究。","authors":"Chu Li, Jingjing Sheng, Yawei Zhang, Qiaofei Lyu, Liwei Yang, Zixing Zhong","doi":"10.1097/HJH.0000000000003791","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Thyroid dysfunction has been associated with preeclampsia (PE) during pregnancy, but the observational results are conflicting. Our study aims to investigate the causal association and direction between genetically predicted effects of thyroid function on PE and vice versa via two large summary genetic data.</p><p><strong>Methods: </strong>We conducted a two-sample bidirectional Mendelian randomization (MR) study using genome-wide association studies (GWAS) summary data from two primarily European cohorts: the ThyroidOmics Consortium and the FinnGen Biobank. We applied the random effects inverse variance weighted (IVW) as our main analysis. MR-Egger and weighted median were used for sensitivity analysis. Statistical analysis was performed using the R program (version 4.3.0) with the two-sample package (version 0.5.6).</p><p><strong>Results: </strong>The results suggest that genetically predicted hyperthyroidism is causally associated with PE during pregnancy [ β = 0.06, 95% confidence interval (CI): 1.01-1.12; P = 0.02], and genetically predicted hypothyroidism is also causally associated with PE during pregnancy ( β = 0.11, 95% CI: 1.03-1.21; P = 0.01). These effects were further confirmed with sensitivity analysis. Conversely, preeclampsia is not associated with the risk of thyroid dysfunction in the reverse MR results: thyroid-stimulating hormone ( β = 0.00, P = 0.92), free thyroxine (FT4) ( β = -0.01, P = 0.56), triiodothyronine (FT3) ( β = -0.00, P = 0.72), FT3/FT4 ( β = -0.01, P = 0.38), thyroid peroxidase antibodies ( β = -0.01, P = 0.64), hyperthyroidism ( β = -0.11, P = 0.29) and hypothyroidism ( β = 0.04, P = 0.12).</p><p><strong>Conclusion: </strong>Our study suggests that hyper-/hypo-thyroidism causally affected preeclampsia, while PE is not causally associated with thyroid dysfunctions.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"2075-2083"},"PeriodicalIF":3.3000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thyroid function and preeclampsia: a two-sample bidirectional Mendelian randomization study.\",\"authors\":\"Chu Li, Jingjing Sheng, Yawei Zhang, Qiaofei Lyu, Liwei Yang, Zixing Zhong\",\"doi\":\"10.1097/HJH.0000000000003791\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Thyroid dysfunction has been associated with preeclampsia (PE) during pregnancy, but the observational results are conflicting. Our study aims to investigate the causal association and direction between genetically predicted effects of thyroid function on PE and vice versa via two large summary genetic data.</p><p><strong>Methods: </strong>We conducted a two-sample bidirectional Mendelian randomization (MR) study using genome-wide association studies (GWAS) summary data from two primarily European cohorts: the ThyroidOmics Consortium and the FinnGen Biobank. We applied the random effects inverse variance weighted (IVW) as our main analysis. MR-Egger and weighted median were used for sensitivity analysis. Statistical analysis was performed using the R program (version 4.3.0) with the two-sample package (version 0.5.6).</p><p><strong>Results: </strong>The results suggest that genetically predicted hyperthyroidism is causally associated with PE during pregnancy [ β = 0.06, 95% confidence interval (CI): 1.01-1.12; P = 0.02], and genetically predicted hypothyroidism is also causally associated with PE during pregnancy ( β = 0.11, 95% CI: 1.03-1.21; P = 0.01). These effects were further confirmed with sensitivity analysis. Conversely, preeclampsia is not associated with the risk of thyroid dysfunction in the reverse MR results: thyroid-stimulating hormone ( β = 0.00, P = 0.92), free thyroxine (FT4) ( β = -0.01, P = 0.56), triiodothyronine (FT3) ( β = -0.00, P = 0.72), FT3/FT4 ( β = -0.01, P = 0.38), thyroid peroxidase antibodies ( β = -0.01, P = 0.64), hyperthyroidism ( β = -0.11, P = 0.29) and hypothyroidism ( β = 0.04, P = 0.12).</p><p><strong>Conclusion: </strong>Our study suggests that hyper-/hypo-thyroidism causally affected preeclampsia, while PE is not causally associated with thyroid dysfunctions.</p>\",\"PeriodicalId\":16043,\"journal\":{\"name\":\"Journal of Hypertension\",\"volume\":\" \",\"pages\":\"2075-2083\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hypertension\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/HJH.0000000000003791\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hypertension","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/HJH.0000000000003791","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/12 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
Thyroid function and preeclampsia: a two-sample bidirectional Mendelian randomization study.
Background: Thyroid dysfunction has been associated with preeclampsia (PE) during pregnancy, but the observational results are conflicting. Our study aims to investigate the causal association and direction between genetically predicted effects of thyroid function on PE and vice versa via two large summary genetic data.
Methods: We conducted a two-sample bidirectional Mendelian randomization (MR) study using genome-wide association studies (GWAS) summary data from two primarily European cohorts: the ThyroidOmics Consortium and the FinnGen Biobank. We applied the random effects inverse variance weighted (IVW) as our main analysis. MR-Egger and weighted median were used for sensitivity analysis. Statistical analysis was performed using the R program (version 4.3.0) with the two-sample package (version 0.5.6).
Results: The results suggest that genetically predicted hyperthyroidism is causally associated with PE during pregnancy [ β = 0.06, 95% confidence interval (CI): 1.01-1.12; P = 0.02], and genetically predicted hypothyroidism is also causally associated with PE during pregnancy ( β = 0.11, 95% CI: 1.03-1.21; P = 0.01). These effects were further confirmed with sensitivity analysis. Conversely, preeclampsia is not associated with the risk of thyroid dysfunction in the reverse MR results: thyroid-stimulating hormone ( β = 0.00, P = 0.92), free thyroxine (FT4) ( β = -0.01, P = 0.56), triiodothyronine (FT3) ( β = -0.00, P = 0.72), FT3/FT4 ( β = -0.01, P = 0.38), thyroid peroxidase antibodies ( β = -0.01, P = 0.64), hyperthyroidism ( β = -0.11, P = 0.29) and hypothyroidism ( β = 0.04, P = 0.12).
Conclusion: Our study suggests that hyper-/hypo-thyroidism causally affected preeclampsia, while PE is not causally associated with thyroid dysfunctions.
期刊介绍:
The Journal of Hypertension publishes papers reporting original clinical and experimental research which are of a high standard and which contribute to the advancement of knowledge in the field of hypertension. The Journal publishes full papers, reviews or editorials (normally by invitation), and correspondence.