主动脉僵硬度的估计值与测量值:糖尿病、慢性肾病、性别和身高的影响。

IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Journal of Hypertension Pub Date : 2024-12-01 Epub Date: 2024-08-23 DOI:10.1097/HJH.0000000000003845
Nadège Côté, Catherine Fortier, Kaveh Jafari, Mathilde Paré, Saliha Addour, Rémi Goupil, Mohsen Agharazii
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引用次数: 0

摘要

背景:主动脉僵硬度是通过颈动脉-股动脉脉搏波速度(PWV)测量的,但也可以根据年龄和肱动脉平均压力(MAP)来估算(ePWV)。然而,糖尿病和/或慢性肾病(DM/CKD)可能会对动脉壁造成更明显的损伤,从而改变压力和脉搏波速度之间的关系。此外,性别和身高也会通过与动脉直径和路径长度的关系影响脉搏波速度。本研究旨在量化 DM/CKD、性别和身高对 ePWV 预测脉搏波速度有效性的影响程度:这项横断面研究使用 Complior 和二次导数传输时间算法(PWV2nd)评估了主动脉僵化高风险成年参与者的脉搏波速度。PWV2nd 被转换成相切脉搏波速度(PWVITc),而 ePWV 则使用动脉僵化参考值合作公式计算:在 825 名患者(62% 为男性)中,平均年龄为 60 ± 17 岁,34% 患有糖尿病,69% 患有慢性肾脏病,24% 没有糖尿病/慢性肾脏病。MAP、ePWV、PWV2nd 和 PWVITc 分别为 96 ± 14 mmHg、9.8 (8.1-11.8) m/s、9.5 (7.8-11.9) m/s 和 11.3 (8.8-15.9) m/s。DM/CKD、性别和 ePWV 的预测值之间存在明显的交互作用。身高的增加降低了截距,但并不影响估测脉搏波速度与测量脉搏波速度之间关系的斜率:这些研究结果表明,目前的 ePWV 方程不能准确预测 DM/CKD 患者的脉搏波速度,未来的 ePWV 方程还应考虑性别和身高因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimated versus measured aortic stiffness: implications of diabetes, chronic kidney disease, sex and height.

Background: Aortic stiffness is measured by carotid-femoral pulse wave velocity (PWV), but it can also be estimated (ePWV) based on age and brachial mean arterial pressure (MAP). However, diabetes mellitus and/or chronic kidney disease (DM/CKD) may cause more pronounced damage to the arterial wall, changing the pressure and PWV relationship. Furthermore, sex and height could affect PWV through their relationship to the arterial diameter and path length. The aim of the present study was to quantify the extent to which DM/CKD, sex and height affect the validity of ePWV in predicting PWV.

Methods: This cross-sectional study evaluated PWV in adult participants at high risk of aortic stiffness, using Complior and the second derivative transit time algorithm (PWV 2nd ). PWV 2nd was converted into intersecting tangent PWV (PWV ITc ), and ePWV was calculated using the Reference Values for Arterial Stiffness Collaboration formulas.

Results: Among 825 patients (62% males), the mean age was 60 ± 17 years, 34% had diabetes mellitus, 69% had CKD, and 24% did not have DM/CKD. MAP, ePWV, PWV 2nd , and PWV ITc were, respectively, 96 ± 14 mmHg, 9.8 (8.1-11.8) m/s, 9.5 (7.8-11.9) m/s and 11.3 (8.8-15.9) m/s. There was a significant interaction between DM/CKD, sex, and the predictive value of ePWV. Increasing height lowered the intercept but did not affect the slope of the relationship between estimated and measured PWVs.

Conclusion: These findings suggest that the current ePWV equations do not accurately predict PWV in patients with DM/CKD, and that sex and height should also be considered in the future ePWV equations.

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来源期刊
Journal of Hypertension
Journal of Hypertension 医学-外周血管病
CiteScore
7.90
自引率
6.10%
发文量
1389
审稿时长
3 months
期刊介绍: The Journal of Hypertension publishes papers reporting original clinical and experimental research which are of a high standard and which contribute to the advancement of knowledge in the field of hypertension. The Journal publishes full papers, reviews or editorials (normally by invitation), and correspondence.
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