白细胞介素-6 水平与中风的关系:系统综述与荟萃分析。

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Xinyi Huang, Manman Zhang, Jiaojiao Wang, Fuyong Hu
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引用次数: 0

摘要

目的:我们旨在评估白细胞介素-6(IL-6)表达水平与中风的关系:我们旨在评估白细胞介素-6(IL-6)表达水平与脑卒中的关系:根据设定的检索策略,我们使用 PubMed 系统地筛选了相关研究,并从文献中提取了有关 IL-6 的研究结果进行综合定量分析,以探讨 IL-6 水平与脑卒中风险之间的关系:本研究共收录了 15 篇文献,共计 1696 名参与者,其中病例组 975 例,对照组 721 例。元分析显示,中风人群的 IL-6 水平明显高于对照组(标准化平均差 = 1.22,95% 置信区间 = 0.79-1.64)。亚组分析显示,两组间 IL-6 检测方法的异质性无明显差异(I2 = 0,P = 0.47)。地理区域的异质性检验结果差异有统计学意义(I2 = 89.7%,P 0.01)。参与者平均年龄的异质性检验结果也具有统计学意义(I2 = 84.3%,P = 0.01):本研究结果表明,IL-6 可能与脑卒中的发生密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between interleukin-6 levels and stroke: a systematic review and meta-analysis.

Objectives: We aimed to evaluate the association of interleukin-6 (IL-6) expression levels with stroke.

Methods: According to the set search strategy, we systematically screened relevant studies using PubMed and extracted study results regarding IL-6 from the literature for comprehensive quantitative analysis to explore the relationship between IL-6 level and stroke risk.

Results: This study included 15 publications with a total of 1696 participants, with 975 cases in the case group and 721 cases in the control group. Meta-analysis showed that IL-6 levels were significantly higher in the stroke population than those in the control group (standardized mean difference = 1.22, 95% confidence interval = 0.79-1.64). Subgroup analysis showed that there was no significant difference in heterogeneity for IL-6 detection methods between the two groups (I2 = 0, P = 0.47). The difference in heterogeneity test results regarding geographic region was statistically significant (I2 = 89.7%, P < 0.01). The results of heterogeneity testing for mean participant age were also statistically significant (I2 = 84.3%, P = 0.01).

Conclusion: The present study results showed that IL-6 may be significantly associated with stroke development.

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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
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