AARS 在线:有关氨基酰-tRNA 合成酶的结构、功能和进化的合作数据库。

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
IUBMB Life Pub Date : 2024-09-09 DOI:10.1002/iub.2911
Jordan Douglas, Haissi Cui, John J. Perona, Oscar Vargas-Rodriguez, Henna Tyynismaa, Claudia Alvarez Carreño, Jiqiang Ling, Lluís Ribas de Pouplana, Xiang-Lei Yang, Michael Ibba, Hubert Becker, Frédéric Fischer, Marie Sissler, Charles W. Carter Jr, Peter R. Wills
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引用次数: 0

摘要

氨基酰-tRNA 合成酶(aaRS)是在所有已知生物系统中执行遗传密码的一大类酶。它们将氨基酸连接到同源的 tRNA 上,在氨基酰化之外还从事各种翻译和非翻译活动,并与许多遗传疾病有关。aaRS 具有微妙的本体特征,其结构和功能特异性因生物体和蛋白质而异。在整个生命树中,22 个编码氨基酸由 16 个 I 类 aaRS 进化家族和 21 个 II 类 aaRS 家族处理。我们介绍了 AARS Online,这是一个类似维基百科的互动工具,由国际领域专家联盟策划。该平台通过展示在分类学上具有多样性的 aaRS 序列和结构,将有关 aaRS 的现有知识系统化。通过其图形用户界面,AARS Online 可以在蛋白质序列和结构之间进行无缝探索,为非专业人员提供了友好的资料介绍,也为专家提供了有用的资源。可以提取经过整理的多序列比对,用于下游分析。AARS Online 可在 www.aars.online 上访问,是深入研究 aaRS 世界的免费资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases

AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases

The aminoacyl-tRNA synthetases (aaRS) are a large group of enzymes that implement the genetic code in all known biological systems. They attach amino acids to their cognate tRNAs, moonlight in various translational and non-translational activities beyond aminoacylation, and are linked to many genetic disorders. The aaRS have a subtle ontology characterized by structural and functional idiosyncrasies that vary from organism to organism, and protein to protein. Across the tree of life, the 22 coded amino acids are handled by 16 evolutionary families of Class I aaRS and 21 families of Class II aaRS. We introduce AARS Online, an interactive Wikipedia-like tool curated by an international consortium of field experts. This platform systematizes existing knowledge about the aaRS by showcasing a taxonomically diverse selection of aaRS sequences and structures. Through its graphical user interface, AARS Online facilitates a seamless exploration between protein sequence and structure, providing a friendly introduction to the material for non-experts and a useful resource for experts. Curated multiple sequence alignments can be extracted for downstream analyses. Accessible at www.aars.online, AARS Online is a free resource to delve into the world of the aaRS.

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来源期刊
IUBMB Life
IUBMB Life 生物-生化与分子生物学
CiteScore
10.60
自引率
0.00%
发文量
109
审稿时长
4-8 weeks
期刊介绍: IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.
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