使用高强度聚焦超声与根治手术治疗非转移性胰腺癌的回顾性比较研究。

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-09-08 DOI:10.1080/02656736.2024.2398557
Li Yu, Yunfei Liu, Zhiqiang Li, Yanyan Huang, Guangping Tu, Qiuling Shi, Lang Chen, Xiao Yu
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引用次数: 0

摘要

摘要比较高强度聚焦超声(HIFU)和根治性手术治疗非转移性胰腺癌(PC)的有效性和安全性:我们回顾性分析了2020年1月至2021年12月在湘雅三医院接受HIFU(43例)或手术(46例)治疗的89例I/II/III期PC患者。对疼痛缓解程度、卡诺夫斯基表现量表(KPS)、总生存率(OS)、治疗相关并发症以及影响OS的风险因素进行了评估:结果:两组患者治疗后30天的疼痛缓解率无明显差异。然而,与手术组相比,HIFU 组治疗后的 VAS 评分明显较低(p = 0.019)。手术组治疗后 30 天的 KPS 低于治疗前的 KPS(70 vs 80;p = 0.015)。这种关系在 HIFU 组则相反(80 vs 70; p = 0.024)。中位生存期手术优于 HIFU(23 个月 vs 10 个月;p p = 0.177)。并发症≥III级的比例,HIFU组为2.33%,手术组为32.6%。多变量分析显示,年龄、KPS和治疗方法是OS的独立预后因素:结论:就早期KPS、VAS改善和安全性而言,HIFU治疗胰腺癌比手术治疗更有优势;但是,长期结果更倾向于手术治疗。对于III期疾病,HIFU的总生存率并不亚于手术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery.

Objective: To compare the efficacy and safety of high-intensity focused ultrasound (HIFU) and radical surgery for non-metastatic pancreatic cancer (PC).

Materials and methods: We retrospectively analyzed 89 stage I/II/III PC patients who underwent HIFU (n = 43) or surgery (n = 46) at the Third Xiangya Hospital from January 2020 to December 2021. Pain relief, Karnofsky Performance Scale (KPS), overall survival (OS), treatment-related complications and risk factors for OS were assessed.

Results: There was no significant difference in the pain relief rate at 30 days post-treatment between the two groups. However, compared with the surgery group, the HIFU group showed significantly lower post-treatment VAS scores (p = 0.019). In the surgery group, the KPS at 30 days post-treatment was lower than pretreatment KPS (70 vs 80; p = 0.015). This relationship was reversed in the HIFU group (80 vs 70; p = 0.024). Median OS favored surgery over HIFU (23 vs 10 months; p < 0.001), with a higher 1-year OS rate (69.57% vs 32.6%; p < 0.001). However, there was no significant difference in OS between the two groups for stage III patients (p = 0.177). Complications rated ≥ grade III were 2.33% in the HIFU group and 32.6% in the surgery group. Multivariate analyses showed that age, KPS, and treatment methods were independent prognostic factors for OS.

Conclusion: HIFU demonstrates advantages over surgery in terms of early KPS, VAS improvements, and safety for pancreatic cancer; however, long-term outcomes favor surgery. For III-stage disease, HIFU was noninferior to surgery in overall survival.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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