健康和疾病中心脏的 IGF 信号转导。

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow) Pub Date : 2024-08-30 DOI:10.1134/S0006297924080042

Daria A. Adasheva, Daria V. Serebryanaya

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引用次数: 0

摘要

心血管系统的正常运行是人体最重要的过程之一。心脏的生理过程受心脏保护机制和病理机制的平衡调节。胰岛素样生长因子系统（IGF 系统，IGF 信号通路）在调节各种细胞和组织的生长发育方面发挥着关键作用。在心肌中，IGF 系统具有保护心脏的作用，同时也参与病理过程。本综述总结了有关 IGF 信号在心血管保护和各种心血管疾病发病机制中作用的最新数据，并分析了这些作用在各种情况下的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

IGF Signaling in the Heart in Health and Disease

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IGF Signaling in the Heart in Health and Disease

One of the most vital processes of the body is the cardiovascular system’s proper operation. Physiological processes in the heart are regulated by the balance of cardioprotective and pathological mechanisms. The insulin-like growth factor system (IGF system, IGF signaling pathway) plays a pivotal role in regulating growth and development of various cells and tissues. In myocardium, the IGF system provides cardioprotective effects as well as participates in pathological processes. This review summarizes recent data on the role of IGF signaling in cardioprotection and pathogenesis of various cardiovascular diseases, as well as analyzes severity of these effects in various scenarios.

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来源期刊

Biochemistry (Moscow) 生物-生化与分子生物学

CiteScore

4.70

自引率

3.60%

发文量

139

审稿时长

2 months

期刊介绍： Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).