合成嵌入石墨氮化碳纳米复合材料中的羟基磷灰石锶和羟基磷灰石锶的另一种方法,用于潜在的组织工程应用

IF 4.3 3区 材料科学 Q2 MATERIALS SCIENCE, COATINGS & FILMS
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引用次数: 0

摘要

锶羟基磷灰石在生物医学工程,特别是药物输送和组织修复方面具有广阔的应用前景,因而备受关注。为了在骨科手术中得到潜在的应用,我们采用了一种新的方法来制备高纯度和均匀性更好的羟基磷灰石锶(Sr-HAP)和石墨氮化碳包裹的羟基磷灰石锶(Sr-HAP@gCN)。锶和钙在人体内的生理途径与导致骨矿物质沉积的趋势相同。本研究采用水热法合成 Sr-HAP 和 Sr-HAP@gCN,以获得一种具有潜在生物相容性和药理活性的理想生物材料。对制备的 Sr-HAP 和 Sr-HAP@gCN 进行了 X 射线衍射 (XRD)、傅立叶变换红外光谱分析 (FTIR)、电子采样、原子力显微镜研究、热重分析和拉曼光谱分析,以确定锶的掺入效率。此外,还使用雷沙霉素微滴定法和 MTT 法评估了抗菌敏感性和生物相容性。通过傅立叶变换红外光谱研究证明了 Sr-HAP 的典型晶相以及 Sr-HAP@gCN 中的相变,特别是 gCN 与 Sr-HAP 之间的界面连接。拉曼光谱显示了对称和不对称 PO 振荡的典型特征,这与锶的添加引起的线性变化有关。在模拟体液(SBF)中浸泡 21 天后,Sr-HAP 和 Sr-HAP@gCN 在诱导矿化方面的生物效应相当显著。抗菌敏感性和生物相容性方面的良好结果证明,这种材料是药物输送和骨填充应用的理想选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An alternative approach in the synthesis of strontium-hydroxyapatite and strontium hydroxyapatite embedded in graphitic carbon nitride nanocomposites for potential tissue engineering applications

An alternative approach in the synthesis of strontium-hydroxyapatite and strontium hydroxyapatite embedded in graphitic carbon nitride nanocomposites for potential tissue engineering applications

Sr-hydroxyapatite has drawn much attention with promising applications in biomedical engineering especially in drug delivery and tissue repair. A novel protocol for the preparation of Strontium hydroxyapatite (Sr-HAP) and Strontium hydroxyapatite encapsulated by graphitic carbon nitride (Sr-HAP@gCN) with high purity and better homogeneity was adopted for potential use in orthopaedic surgeries. The physiological pathway of Strontium and calcium inside humans follow the same trend leading to the mineral deposition of the bone. In the present study, a novel attempt in synthesizing Sr-HAP and Sr-HAP@gCN by the hydrothermal method is proposed for obtaining an ideal biomaterial with potential biocompatibility and pharmacological activity. Phase identification by X-ray diffraction (XRD), Fourier transform Infra-Red spectroscopic analysis (FTIR), Electron & atomic force microscopic studies, Thermogravimetric and Raman spectroscopic analysis was performed on the prepared Sr-HAP and Sr-HAP@gCN to characterize the incorporation efficiency of Strontium. Resazurin microtiter assay and MTT assay were used to evaluate antimicrobial susceptibility and biocompatibility. The typical crystal phase of Sr-HAP and a phase change in Sr-HAP@gCN have been demonstrated with special reference to the interfacial connection between gCN and Sr-HAP through FT-IR studies. Raman spectroscopy revealed the archetypal signature of symmetric and asymmetric PO vibrations pertaining to linearity change with the addition of Strontium. The biological effect of Sr-HAP and Sr-HAP@gCN was quite significant in inducing mineralization when kept immersed in simulated body fluid (SBF) for 21 days. Promising results pertaining to antimicrobial susceptibility and biocompatibility have been proved as an encouraging choice for drug delivery applications and bone filling applications.

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来源期刊
Diamond and Related Materials
Diamond and Related Materials 工程技术-材料科学:综合
CiteScore
6.00
自引率
14.60%
发文量
702
审稿时长
2.1 months
期刊介绍: DRM is a leading international journal that publishes new fundamental and applied research on all forms of diamond, the integration of diamond with other advanced materials and development of technologies exploiting diamond. The synthesis, characterization and processing of single crystal diamond, polycrystalline films, nanodiamond powders and heterostructures with other advanced materials are encouraged topics for technical and review articles. In addition to diamond, the journal publishes manuscripts on the synthesis, characterization and application of other related materials including diamond-like carbons, carbon nanotubes, graphene, and boron and carbon nitrides. Articles are sought on the chemical functionalization of diamond and related materials as well as their use in electrochemistry, energy storage and conversion, chemical and biological sensing, imaging, thermal management, photonic and quantum applications, electron emission and electronic devices. The International Conference on Diamond and Carbon Materials has evolved into the largest and most well attended forum in the field of diamond, providing a forum to showcase the latest results in the science and technology of diamond and other carbon materials such as carbon nanotubes, graphene, and diamond-like carbon. Run annually in association with Diamond and Related Materials the conference provides junior and established researchers the opportunity to exchange the latest results ranging from fundamental physical and chemical concepts to applied research focusing on the next generation carbon-based devices.
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