免疫功能正常宿主的脑膜孢子丝菌病：病例报告

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports Pub Date : 2024-09-01 DOI:10.1016/j.mmcr.2024.100665

Victor Teatini Ribeiro , Rachel Basques Caligiorne , Aldrin Pedroza Martins , Antônio Pereira Gomes Neto , Paulo Pereira Christo

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引用次数: 0

摘要

一名 78 岁的妇女因精神状态改变而入院。诊断并治疗了低钠血症。尽管血钠正常，但她仍有精神错乱。没有头痛、发热或局灶性体征。脑脊液分析显示为慢性脑膜炎；核磁共振成像显示为基底增强。她接受了结核病的经验性治疗，但病情没有改善。脑脊液中的孢子丝虫 PCR 呈阳性。在接受两性霉素治疗和口服伊曲康唑治疗后，她的认知能力完全恢复。后续的脑脊液检查结果正常。本报告说明，在免疫功能正常者慢性脑膜炎的鉴别诊断中需要考虑孢子丝菌病，并说明 PCR 作为诊断工具的重要性。

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Meningeal sporotrichosis in an immunocompetent host: A case report

A 78-year-old woman presented to hospital with altered mental status. Hyponatremia was diagnosed and treated. She maintained mental confusion despite normal sodium. No headache, fever or focal signs were present. CSF analysis showed chronic meningitis; MRI demonstrated basilar enhancement. She was empirically treated for tuberculosis, with no improvement. PCR for Sporothrix in the CSF was positive. After treatment with Amphotericin followed by oral itraconazole, she completely recovered her cognitive abilities. Follow-up CSF was normal. This report illustrates the need to consider sporotrichosis in the differential diagnosis of chronic meningitis in immunocompetent, and the importance of PCR as a diagnostic tool.

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来源期刊

Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

47 days