{"title":"中红外化学/生物传感器的最新进展和趋势","authors":"","doi":"10.1016/j.trac.2024.117916","DOIUrl":null,"url":null,"abstract":"<div><p>The Mid-Infrared (MIR) spectral regime has gained interest in biosensor research due to the unique excitation of specific molecular vibrational, rovibrational, and rotational modes of biomarkers and biological molecules, offering inherent selectivity for biomarker detection, which is a key asset for biomedical applications. This review focuses on the role of mid-infrared sensing technologies in biomedicine, emphasizing the crucial requirement for accurate detection and real-time monitoring of biological processes in early disease diagnosis and monitoring of disease progression. Highlighted examples provide insight into the effectiveness of MIR optical biosensors for addressing key biomarkers, underscoring their potential impact in areas including but not limited to personalized medicine and clinical research. Furthermore, we discuss how recently designed and implemented microstructures enhance the sensitivity within these application scenarios. These advancements will be complemented by technical challenges inherent to this evolving field, addressing further sensitivity enhancement, device miniaturization, and system integration, along with advanced data analysis. Future strategies discussed in this review contextualize the convergence of MIR sensing, biomedicine, and the integration of artificial intelligence for comprehensive data analysis and interpretation.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165993624003996/pdfft?md5=d4498153dcc5ed9a59330389f80819a0&pid=1-s2.0-S0165993624003996-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Recent advances and trends in mid-infrared chem/bio sensors\",\"authors\":\"\",\"doi\":\"10.1016/j.trac.2024.117916\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The Mid-Infrared (MIR) spectral regime has gained interest in biosensor research due to the unique excitation of specific molecular vibrational, rovibrational, and rotational modes of biomarkers and biological molecules, offering inherent selectivity for biomarker detection, which is a key asset for biomedical applications. This review focuses on the role of mid-infrared sensing technologies in biomedicine, emphasizing the crucial requirement for accurate detection and real-time monitoring of biological processes in early disease diagnosis and monitoring of disease progression. Highlighted examples provide insight into the effectiveness of MIR optical biosensors for addressing key biomarkers, underscoring their potential impact in areas including but not limited to personalized medicine and clinical research. Furthermore, we discuss how recently designed and implemented microstructures enhance the sensitivity within these application scenarios. These advancements will be complemented by technical challenges inherent to this evolving field, addressing further sensitivity enhancement, device miniaturization, and system integration, along with advanced data analysis. Future strategies discussed in this review contextualize the convergence of MIR sensing, biomedicine, and the integration of artificial intelligence for comprehensive data analysis and interpretation.</p></div>\",\"PeriodicalId\":439,\"journal\":{\"name\":\"Trends in Analytical Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":11.8000,\"publicationDate\":\"2024-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0165993624003996/pdfft?md5=d4498153dcc5ed9a59330389f80819a0&pid=1-s2.0-S0165993624003996-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Analytical Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165993624003996\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Analytical Chemistry","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165993624003996","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Recent advances and trends in mid-infrared chem/bio sensors
The Mid-Infrared (MIR) spectral regime has gained interest in biosensor research due to the unique excitation of specific molecular vibrational, rovibrational, and rotational modes of biomarkers and biological molecules, offering inherent selectivity for biomarker detection, which is a key asset for biomedical applications. This review focuses on the role of mid-infrared sensing technologies in biomedicine, emphasizing the crucial requirement for accurate detection and real-time monitoring of biological processes in early disease diagnosis and monitoring of disease progression. Highlighted examples provide insight into the effectiveness of MIR optical biosensors for addressing key biomarkers, underscoring their potential impact in areas including but not limited to personalized medicine and clinical research. Furthermore, we discuss how recently designed and implemented microstructures enhance the sensitivity within these application scenarios. These advancements will be complemented by technical challenges inherent to this evolving field, addressing further sensitivity enhancement, device miniaturization, and system integration, along with advanced data analysis. Future strategies discussed in this review contextualize the convergence of MIR sensing, biomedicine, and the integration of artificial intelligence for comprehensive data analysis and interpretation.
期刊介绍:
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.