中红外化学/生物传感器的最新进展和趋势

IF 11.8 1区 化学 Q1 CHEMISTRY, ANALYTICAL
Gabriela Flores Rangel , Lorena Diaz de León Martínez , Lisa Sophie Walter , Boris Mizaikoff
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引用次数: 0

摘要

中红外(MIR)光谱系统在生物传感器研究中备受关注,因为它能激发生物标记物和生物分子的特定分子振动、振荡和旋转模式,为生物标记物检测提供固有的选择性,这是生物医学应用的关键资产。本综述侧重于中红外传感技术在生物医学中的作用,强调在早期疾病诊断和疾病进展监测中准确检测和实时监测生物过程的关键要求。重点介绍的实例深入说明了中红外光学生物传感器在处理关键生物标记物方面的有效性,强调了它们在包括但不限于个性化医疗和临床研究等领域的潜在影响。此外,我们还讨论了最近设计和实施的微结构如何在这些应用场景中提高灵敏度。在取得这些进展的同时,这一不断发展的领域也面临着固有的技术挑战,包括进一步提高灵敏度、设备微型化、系统集成以及先进的数据分析。本综述中讨论的未来战略将结合近红外传感、生物医学和人工智能的融合,以实现全面的数据分析和解读。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent advances and trends in mid-infrared chem/bio sensors

The Mid-Infrared (MIR) spectral regime has gained interest in biosensor research due to the unique excitation of specific molecular vibrational, rovibrational, and rotational modes of biomarkers and biological molecules, offering inherent selectivity for biomarker detection, which is a key asset for biomedical applications. This review focuses on the role of mid-infrared sensing technologies in biomedicine, emphasizing the crucial requirement for accurate detection and real-time monitoring of biological processes in early disease diagnosis and monitoring of disease progression. Highlighted examples provide insight into the effectiveness of MIR optical biosensors for addressing key biomarkers, underscoring their potential impact in areas including but not limited to personalized medicine and clinical research. Furthermore, we discuss how recently designed and implemented microstructures enhance the sensitivity within these application scenarios. These advancements will be complemented by technical challenges inherent to this evolving field, addressing further sensitivity enhancement, device miniaturization, and system integration, along with advanced data analysis. Future strategies discussed in this review contextualize the convergence of MIR sensing, biomedicine, and the integration of artificial intelligence for comprehensive data analysis and interpretation.

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来源期刊
Trends in Analytical Chemistry
Trends in Analytical Chemistry 化学-分析化学
CiteScore
20.00
自引率
4.60%
发文量
257
审稿时长
3.4 months
期刊介绍: TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.
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