通过 C-C 偶联反应合成新的 4，5-二取代-6-甲基-2-（甲硫基）嘧啶

IF 2.1 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Sulfur Chemistry Pub Date : 2024-09-02 DOI:10.1080/17415993.2024.2390541

引用次数: 0

摘要

通过 Sonogashira 反应，成功开发出了一种简便的 4、5-二取代-6-甲基-2-（甲硫基）嘧啶的合成方法。在 Pd-Cu 催化剂存在下，胺、末端炔和 4-氯-5-碘-6-甲基-2-（甲硫基）嘧啶在 DMF 中于 80°C 下进行一锅多步反应，可得到 4，5-二取代-6-甲基-2-（甲硫基）嘧啶衍生物，收率中等至良好。

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Synthesis of new 4, 5-disubstituted-6-methyl-2-(methylthio) pyrimidines via C-C coupling reactions

A convenient synthetic protocol for diverse 4, 5-disubstituted-6-methyl-2-(methylthio)pyrimidines was successfully developed by Sonogashira reactions. In the presence of Pd-Cu catalysts, one-pot, multi-step reaction of amines, terminal alkynes, and 4-chloro-5-iodo-6-methyl-2-(methylthio)pyrimidine in DMF at 80°C resulted in 4, 5-disubstituted-6-methyl-2-(methylthio)pyrimidine derivatives in moderate to good yields.

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来源期刊

Journal of Sulfur Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.10

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science. Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.