基于微生物组的生物标记物的现状与未来:多学科德尔菲共识。

IF 20.9 1区 生物学 Q1 INFECTIOUS DISEASES
Julie Rodriguez, Zahra Hassani, Carolina Alves Costa Silva, Fay Betsou, Federica Carraturo, Alessio Fasano, Mads Israelsen, Anandhi Iyappan, Aleksander Krag, Amira Metwaly, Robert Schierwagen, Jonel Trebicka, Hub Zwart, Joel Doré, Magali Cordaillat-Simmons, Celine Druart
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引用次数: 0

摘要

虽然微生物组特征已在各种情况下(即非传染性疾病的发病机理和治疗反应)得到确定,但目前临床实践中还没有使用合格的基于微生物组的生物标志物。人类微生物组行动联盟发起了一项德尔菲调查,以就开发合格的基于微生物组的生物标记物的需求、挑战和限制达成共识。调查问卷由科学委员会通过文献查阅和专家访谈制定。为确保调查结果的广泛适用性,邀请了 307 位专家参与;其中 114 位专家对第一轮调查做出了回应,93 位专家完成了第二轮和最后一轮调查。调查显示,专家们对基于微生物的生物标记物在若干适应症或病理方面的潜力充满信心。缺乏经过验证的分析方法似乎是阻碍这些生物标志物鉴定的主要因素。调查还显示,只有开发出配套的、经过验证的、解释简单的分子检测方法,才有可能在临床上应用这些生物标记物。该倡议为设计和实施公私合作项目奠定了基础,以克服挑战并促进基于微生物组的生物标记物的临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
State of the art and the future of microbiome-based biomarkers: a multidisciplinary Delphi consensus.

Although microbiome signatures have been identified in various contexts (ie, pathogenesis of non-communicable diseases and treatment response), qualified microbiome-based biomarkers are currently not in use in clinical practice. The Human Microbiome Action consortium initiated a Delphi survey to establish a consensus on the needs, challenges, and limitations in developing qualified microbiome-based biomarkers. The questionnaire was developed by a scientific committee via literature review and expert interviews. To ensure broad applicability of the results, 307 experts were invited to participate; 114 of them responded to the first round of the survey, 93 of whom completed the second and final round as well. The survey highlighted the experts' confidence in the potential of microbiome-based biomarkers for several indications or pathologies. The paucity of validated analytical methods appears to be the principal factor hindering the qualification of these biomarkers. The survey also showed that clinical implementation of these biomarkers would only be possible if kitted and validated molecular assays with simple interpretation are developed. This initiative serves as a foundation for designing and implementing public-private collaborative projects to overcome the challenges and promote clinical application of microbiome-based biomarkers.

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来源期刊
Lancet Microbe
Lancet Microbe Multiple-
CiteScore
27.20
自引率
0.80%
发文量
278
审稿时长
6 weeks
期刊介绍: The Lancet Microbe is a gold open access journal committed to publishing content relevant to clinical microbiologists worldwide, with a focus on studies that advance clinical understanding, challenge the status quo, and advocate change in health policy.
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