抗肿瘤免疫中的 CD4+ T 细胞。

IF 14.3 1区 医学 Q1 ONCOLOGY
Trends in cancer Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI:10.1016/j.trecan.2024.07.009
Elena Montauti, David Y Oh, Lawrence Fong
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引用次数: 0

摘要

癌症免疫疗法的进步改变了癌症治疗,使许多患者获得了前所未有的治疗效果。包括免疫检查点抑制疗法(ICI)、收养 T 细胞疗法(ACTs)和癌症疫苗在内的新型疗法不断增加,反映了癌症免疫疗法的成功。这些治疗方法的疗效通常归功于抗肿瘤 CD8+ T 细胞应答数量和质量的提高。然而,现在人们认识到,CD4+ T 细胞在抗肿瘤免疫反应的起始阶段和效应阶段都发挥着关键作用。除了通过协同刺激和产生细胞因子为 T 细胞提供帮助外,CD4+ T 细胞还能直接对 MHC II 类表达的肿瘤细胞或肿瘤微环境(TME)中的其他细胞产生细胞毒性。TME 中特定 CD4+ T 细胞群的存在及其内在可塑性是决定免疫检查点抑制剂、疫苗和嵌合抗原受体(CAR)T 细胞疗法临床反应的重要因素。了解如何诱导特定 CD4+ T 细胞类型的抗肿瘤功能,同时限制它们的原发肿瘤属性,将使免疫疗法更加成功。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CD4+ T cells in antitumor immunity.

Advances in cancer immunotherapy have transformed cancer care and realized unprecedented responses in many patients. The growing arsenal of novel therapeutics - including immune checkpoint inhibition (ICI), adoptive T cell therapies (ACTs), and cancer vaccines - reflects the success of cancer immunotherapy. The therapeutic benefits of these treatment modalities are generally attributed to the enhanced quantity and quality of antitumor CD8+ T cell responses. Nevertheless, CD4+ T cells are now recognized to play key roles in both the priming and effector phases of the antitumor immune response. In addition to providing T cell help through co-stimulation and cytokine production, CD4+ T cells can also possess cytotoxicity either directly on MHC class II-expressing tumor cells or to other cells within the tumor microenvironment (TME). The presence of specific populations of CD4+ T cells, and their intrinsic plasticity, within the TME can represent an important determinant of clinical response to immune checkpoint inhibitors, vaccines, and chimeric antigen receptor (CAR) T cell therapies. Understanding how the antitumor functions of specific CD4+ T cell types are induced while limiting their protumorigenic attributes will enable more successful immunotherapies.

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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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