调查 2022 年疫情爆发期间罗马艾滋病毒感染者 (PLWH) 群体中猴痘病毒 (MPXV) IgG 抗体的血清流行率：超越传统的高危人群。

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease Pub Date : 2024-09-04 DOI:10.1016/j.tmaid.2024.102757

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引用次数: 0

摘要

背景：高发病率表明，无症状者可能会造成病毒传播。我们开展了这项研究，以评估无症状 PLWH 群体中 IgG 抗 MPXV 的血清流行率，从而分析无症状感染现象的规模：从2022年10月至2023年3月，我们连续采集了在本诊所就诊的艾滋病毒感染者的血清样本。我们用 ELISA 方法评估了冷冻保存样本中针对 MPXV 的 IgG。只有既往未接种过天花或天花疫苗，也未出现过与天花诊断相符的临床表现的患者才被纳入检测范围。21 名参与者的抗 MPXV IgG 检测呈阳性（7.37%，95% CI 4.62-11.0）。血清阳性者主要为男性（15/285，71.4%），女性（6/285，28.6%）和吸毒者（1/285，4.8%）占少数：我们的研究结果表明，即使在传统高危人群之外的人群中，也可能存在无症状的 mpox 感染过程。

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Investigating seroprevalence of IgG antibodies against Monkeypox Virus (MPXV) in a cohort of people living with HIV (PLWH) in Rome, during the 2022 outbreak: Moving beyond traditional at-risk populations

Background

High incidence mpox rates suggest asymptomatic individuals may contribute to virus transmission. We undertook this study to assess the seroprevalence of IgG anti-MPXV in a cohort of asymptomatic PLWH, to analyze the size of the phenomenon of asymptomatic infections.

Materials and methods

From October 2022 to March 2023 we serially collected serum samples from PLWH attending our Clinic. IgG against MPXV have been assessed on stored cryopreserved samples with an ELISA. Only people with no previous reported vaccine against smallpox or mpox nor previous clinical manifestations consistent with a mpox diagnosis were included.

Results

285 PLWH were included. Twenty-one participants tested positive for IgG anti MPXV (7.37 %, 95 % CI 4.62–11.0). Seropositivity was predominant in male (15/285, 71.4) with a small fraction of female (6/285,28.6 %) and PWID (1/285,4.8 %).

Conclusions

Our findings suggest the possibility of an asymptomatic course of the mpox infection even in populations beyond traditional high-risk groups.

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来源期刊

Travel Medicine and Infectious Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECTIOUS DISEASES

CiteScore

19.40

自引率

1.70%

发文量

211

审稿时长

49 days

期刊介绍： Travel Medicine and Infectious Disease Publication Scope: Publishes original papers, reviews, and consensus papers Primary theme: infectious disease in the context of travel medicine Focus Areas: Epidemiology and surveillance of travel-related illness Prevention and treatment of travel-associated infections Malaria prevention and treatment Travellers' diarrhoea Infections associated with mass gatherings Migration-related infections Vaccines and vaccine-preventable disease Global policy/regulations for disease prevention and control Practical clinical issues for travel and tropical medicine practitioners Coverage: Addresses areas of controversy and debate in travel medicine Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease Publication Features: Offers a fast peer-review process Provides early online publication of accepted manuscripts Aims to publish cutting-edge papers