Pierluigi Francesco Salvo , Alessia Sanfilippo , Gianmaria Baldin , Valentina Iannone , Arturo Ciccullo , Damiano Farinacci , Domenico Benvenuto , Alberto Borghetti , Simona Di Giambenedetto , Francesca Lombardi
{"title":"调查 2022 年疫情爆发期间罗马艾滋病毒感染者 (PLWH) 群体中猴痘病毒 (MPXV) IgG 抗体的血清流行率：超越传统的高危人群。","authors":"Pierluigi Francesco Salvo , Alessia Sanfilippo , Gianmaria Baldin , Valentina Iannone , Arturo Ciccullo , Damiano Farinacci , Domenico Benvenuto , Alberto Borghetti , Simona Di Giambenedetto , Francesca Lombardi","doi":"10.1016/j.tmaid.2024.102757","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>High incidence mpox rates suggest asymptomatic individuals may contribute to virus transmission. We undertook this study to assess the seroprevalence of IgG <em>anti</em>-MPXV in a cohort of asymptomatic PLWH, to analyze the size of the phenomenon of asymptomatic infections.</p></div><div><h3>Materials and methods</h3><p>From October 2022 to March 2023 we serially collected serum samples from PLWH attending our Clinic. IgG against MPXV have been assessed on stored cryopreserved samples with an ELISA. Only people with no previous reported vaccine against smallpox or mpox nor previous clinical manifestations consistent with a mpox diagnosis were included.</p></div><div><h3>Results</h3><p>285 PLWH were included. Twenty-one participants tested positive for IgG anti MPXV (7.37 %, 95 % CI 4.62–11.0). Seropositivity was predominant in male (15/285, 71.4) with a small fraction of female (6/285,28.6 %) and PWID (1/285,4.8 %).</p></div><div><h3>Conclusions</h3><p>Our findings suggest the possibility of an asymptomatic course of the mpox infection even in populations beyond traditional high-risk groups.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102757"},"PeriodicalIF":6.3000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000747/pdfft?md5=da722812945ac10b84a9a2a376d715d9&pid=1-s2.0-S1477893924000747-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Investigating seroprevalence of IgG antibodies against Monkeypox Virus (MPXV) in a cohort of people living with HIV (PLWH) in Rome, during the 2022 outbreak: Moving beyond traditional at-risk populations\",\"authors\":\"Pierluigi Francesco Salvo , Alessia Sanfilippo , Gianmaria Baldin , Valentina Iannone , Arturo Ciccullo , Damiano Farinacci , Domenico Benvenuto , Alberto Borghetti , Simona Di Giambenedetto , Francesca Lombardi\",\"doi\":\"10.1016/j.tmaid.2024.102757\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>High incidence mpox rates suggest asymptomatic individuals may contribute to virus transmission. We undertook this study to assess the seroprevalence of IgG <em>anti</em>-MPXV in a cohort of asymptomatic PLWH, to analyze the size of the phenomenon of asymptomatic infections.</p></div><div><h3>Materials and methods</h3><p>From October 2022 to March 2023 we serially collected serum samples from PLWH attending our Clinic. IgG against MPXV have been assessed on stored cryopreserved samples with an ELISA. Only people with no previous reported vaccine against smallpox or mpox nor previous clinical manifestations consistent with a mpox diagnosis were included.</p></div><div><h3>Results</h3><p>285 PLWH were included. Twenty-one participants tested positive for IgG anti MPXV (7.37 %, 95 % CI 4.62–11.0). Seropositivity was predominant in male (15/285, 71.4) with a small fraction of female (6/285,28.6 %) and PWID (1/285,4.8 %).</p></div><div><h3>Conclusions</h3><p>Our findings suggest the possibility of an asymptomatic course of the mpox infection even in populations beyond traditional high-risk groups.</p></div>\",\"PeriodicalId\":23312,\"journal\":{\"name\":\"Travel Medicine and Infectious Disease\",\"volume\":\"62 \",\"pages\":\"Article 102757\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2024-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1477893924000747/pdfft?md5=da722812945ac10b84a9a2a376d715d9&pid=1-s2.0-S1477893924000747-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Travel Medicine and Infectious Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1477893924000747\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Travel Medicine and Infectious Disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1477893924000747","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Investigating seroprevalence of IgG antibodies against Monkeypox Virus (MPXV) in a cohort of people living with HIV (PLWH) in Rome, during the 2022 outbreak: Moving beyond traditional at-risk populations
Background
High incidence mpox rates suggest asymptomatic individuals may contribute to virus transmission. We undertook this study to assess the seroprevalence of IgG anti-MPXV in a cohort of asymptomatic PLWH, to analyze the size of the phenomenon of asymptomatic infections.
Materials and methods
From October 2022 to March 2023 we serially collected serum samples from PLWH attending our Clinic. IgG against MPXV have been assessed on stored cryopreserved samples with an ELISA. Only people with no previous reported vaccine against smallpox or mpox nor previous clinical manifestations consistent with a mpox diagnosis were included.
Results
285 PLWH were included. Twenty-one participants tested positive for IgG anti MPXV (7.37 %, 95 % CI 4.62–11.0). Seropositivity was predominant in male (15/285, 71.4) with a small fraction of female (6/285,28.6 %) and PWID (1/285,4.8 %).
Conclusions
Our findings suggest the possibility of an asymptomatic course of the mpox infection even in populations beyond traditional high-risk groups.
期刊介绍：
Travel Medicine and Infectious Disease
Publication Scope:
Publishes original papers, reviews, and consensus papers
Primary theme: infectious disease in the context of travel medicine
Focus Areas:
Epidemiology and surveillance of travel-related illness
Prevention and treatment of travel-associated infections
Malaria prevention and treatment
Travellers' diarrhoea
Infections associated with mass gatherings
Migration-related infections
Vaccines and vaccine-preventable disease
Global policy/regulations for disease prevention and control
Practical clinical issues for travel and tropical medicine practitioners
Coverage:
Addresses areas of controversy and debate in travel medicine
Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease
Publication Features:
Offers a fast peer-review process
Provides early online publication of accepted manuscripts
Aims to publish cutting-edge papers
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