精神病风险:是时候从经验角度研究一种经济务实的第一步方法来检查异常自我体验了。探索 SQuEASE-11。

IF 5.3 1区 医学 Q1 PSYCHIATRY
Paul Møller, Barnaby Nelson, Patrick D McGorry, Cristina Mei, G Paul Amminger, Hok Pan Yuen, Melissa Kerr, Jessica Spark, Nicky Wallis, Andrea Polari, Shelley Baird, Kate Buccilli, Sarah-Jane A Dempsey, Natalie Ferguson, Melanie Formica, Marija Krcmar, Amelia L Quinn, Yohannes Mebrahtu, Arlan Ruslins, Rebekah Street, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A Niendam, Martha Shumway, Cassandra Wannan
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引用次数: 0

摘要

背景:自 20 世纪 90 年代末以来,全球范围内对精神病前期的科学研究兴趣日益浓厚,并由此推出了多种用于早期检测的临床工具。这些工具的预测准确性有限,因此需要在方法和视角上加以改进。EASE 手册支持对异常自我体验进行系统评估,并提出了一个整体模型,以了解大多数精神病体验最初是如何在统一的、基本的、反思前主观性扭曲的基础上产生的:EASE耗时较长,因此,为了推广使用这一有关精神病风险的重要视角,我们从EASE中选取了一些原型现象和常见现象,将其整合到SQuEASE-11中。为了研究该工具的临床相关性、基本心理测量特性、因子结构以及与金标准工具和完整 EASE 的关系,我们在 STEP 干预试验(澳大利亚墨尔本)中对 328 名临床高危精神病(CHR-P)患者进行了访谈:研究结果:SQuEASE-11 具有中等程度的内部一致性,并显示出两个相关因子。SQuEASE-11与CAARMS、BPRS、SANS、MADRS、DACOBS和SOFAS等广泛使用并经过验证的工具之间存在显著关系。与整个 EASE 的相关性非常强:结论:这 11 个项目并不一定与性欲障碍特别相关,但 SQuEASE-11 似乎是 CHR-P 受试者的临床相关性和简短的补充性一线访谈。它可以为是否需要进行完整的 EASE 访谈提供一个合格的指示,重要的是,它还可以为治疗计划提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Psychosis Risk: Time to Look Empirically at a First-step Economical-pragmatic Way to Examine Anomalous Self-experience. Exploring the SQuEASE-11.

Background: Since the late 1990s, there has been a worldwide surge of scientific interest in the pre-psychotic phase, resulting in the introduction of several clinical tools for early detection. The predictive accuracy of these tools has been limited, motivating the need for methodological and perspectival improvements. The EASE manual supports systematic assessment of anomalous self-experience, and proposes an overall model of understanding how most psychotic experiences may be initially generated on the basis of a unifying, fundamental, pre-reflective distortion of subjectivity.

Study design: The EASE is time-consuming, so in order to spread the use of this essential perspective of psychosis risk we selected prototypical and frequent phenomena from the EASE, combining them into SQuEASE-11. To investigate this instrument for clinical relevance, basic psychometric properties, factor structure, and relationships with gold standard instruments and the full EASE, it was administered as an interview in the STEP intervention trial (Melbourne, Australia), with 328 clinical high-risk for psychosis (CHR-P) patients.

Study results: The SQuEASE-11 had moderate internal consistency and revealed two correlated factors. Significant relationships were observed between the SQuEASE-11 and the widely used and validated instruments CAARMS, BPRS, SANS, MADRS, DACOBS, and SOFAS. The correlation with the full EASE was very strong.

Conclusions: These 11 items do not necessarily relate specifically to ipseity disturbance, but the SQuEASE-11 seems to be a clinically relevant and brief supplementary first-line interview in CHR-P subjects. It may give a qualified indication of the need for a complete EASE interview, and it may also, importantly, inform treatment planning.

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来源期刊
Schizophrenia Bulletin
Schizophrenia Bulletin 医学-精神病学
CiteScore
11.40
自引率
6.10%
发文量
163
审稿时长
4-8 weeks
期刊介绍: Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.
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