{"title":"通过植物与微生物组的相互作用,开启药用植物生物技术中的特殊代谢。","authors":"","doi":"10.1016/j.pbi.2024.102620","DOIUrl":null,"url":null,"abstract":"<div><p>Medicinal plants produce specialized metabolites (SM) that are used as drugs. However, due to low yields of field cultivation and the increasing market demand, this production method often failed to meet supply needs. Biotechnological alternatives, such as <em>in vitro</em> plant cultures, offer promising solutions. Nonetheless, SM production in these systems remains too low for industrial exploitation, necessitating an elicitation step to induce the plant defense metabolism. Traditional elicitation methods mimic environmental conditions that trigger plant-specialized metabolism, often with an artificial signal that mimics microbial interaction. Recent insights into the essential role of the plant microbiota, provides new opportunities for elicitation strategies by microbial coculture in a controlled environment. The successful co-culture of <em>in vitro</em> medicinal plants with synthetic microbial communities could enable sustainable production of pharmaceutically important SM.</p></div>","PeriodicalId":11003,"journal":{"name":"Current opinion in plant biology","volume":null,"pages":null},"PeriodicalIF":8.3000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unlocking specialized metabolism in medicinal plant biotechnology through plant–microbiome interactions\",\"authors\":\"\",\"doi\":\"10.1016/j.pbi.2024.102620\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Medicinal plants produce specialized metabolites (SM) that are used as drugs. However, due to low yields of field cultivation and the increasing market demand, this production method often failed to meet supply needs. Biotechnological alternatives, such as <em>in vitro</em> plant cultures, offer promising solutions. Nonetheless, SM production in these systems remains too low for industrial exploitation, necessitating an elicitation step to induce the plant defense metabolism. Traditional elicitation methods mimic environmental conditions that trigger plant-specialized metabolism, often with an artificial signal that mimics microbial interaction. Recent insights into the essential role of the plant microbiota, provides new opportunities for elicitation strategies by microbial coculture in a controlled environment. The successful co-culture of <em>in vitro</em> medicinal plants with synthetic microbial communities could enable sustainable production of pharmaceutically important SM.</p></div>\",\"PeriodicalId\":11003,\"journal\":{\"name\":\"Current opinion in plant biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.3000,\"publicationDate\":\"2024-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in plant biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1369526624001110\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in plant biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369526624001110","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
药用植物产生的特殊代谢物(SM)可用作药物。然而,由于田间栽培产量低,而市场需求不断增加,这种生产方法往往无法满足供应需求。生物技术替代方法(如体外植物培养)提供了很有前景的解决方案。然而,这些系统中的 SM 产量仍然太低,无法进行工业化生产,因此需要一个诱导步骤来诱导植物的防御新陈代谢。传统的诱导方法是模拟环境条件来触发植物特化的新陈代谢,通常使用模拟微生物相互作用的人工信号。最近对植物微生物群重要作用的深入研究,为在受控环境中通过微生物共培养实施诱导策略提供了新的机会。体外药用植物与合成微生物群落的成功共培养可实现具有重要药用价值的 SM 的可持续生产。
Unlocking specialized metabolism in medicinal plant biotechnology through plant–microbiome interactions
Medicinal plants produce specialized metabolites (SM) that are used as drugs. However, due to low yields of field cultivation and the increasing market demand, this production method often failed to meet supply needs. Biotechnological alternatives, such as in vitro plant cultures, offer promising solutions. Nonetheless, SM production in these systems remains too low for industrial exploitation, necessitating an elicitation step to induce the plant defense metabolism. Traditional elicitation methods mimic environmental conditions that trigger plant-specialized metabolism, often with an artificial signal that mimics microbial interaction. Recent insights into the essential role of the plant microbiota, provides new opportunities for elicitation strategies by microbial coculture in a controlled environment. The successful co-culture of in vitro medicinal plants with synthetic microbial communities could enable sustainable production of pharmaceutically important SM.
期刊介绍:
Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.