Jennifer Pett, Christine Linhart, Nicholas Osborne, Stephen Morrell, Mohammed Fahim, John Knight, Shakila Premaranthne, A W M Wazil, Neelakanthi Ratnatunga, Sulcochana Wijethunga, Shenal Thalgahagoda, Zoltan Endre, Richard Taylor, Nishantha Nanayakkara
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The predominant histopathological entities were grouped and categorised according to diagnosis and stratified by age and sex.</p><p><strong>Results: </strong>The main histopathological entities (all biopsies) were tubulointerstitial nephropathy (TIN) 25% (n = 760), glomerulonephritis (GN) 15% (467), lupus nephropathy 14% (429), focal segmental glomerular sclerosis (FSGS) 10% (297), and IgA nephropathy (IgAN) 8% (242). For adult women ≥ 15 years, the main histopathological entities were lupus nephropathy 24% (325), TIN 17% (228), and GN 16% (217). For adult men ≥ 15 years, the main histopathological entities were TIN 34% (449), GN 14% (180), and IgAN 10% (125). The proportion of TIN in the present study was higher than international studies of a similar size.</p><p><strong>Conclusion: </strong>This is the largest study of renal biopsies reported from Sri Lanka to date. TIN was the most common diagnosis in adults ≥ 15 years at 25%. Notable sex differences showed TIN was the most common histopathology in men (34%) but not in women (17%). No previously published similar study of this size has found TIN as the predominant diagnosis amongst renal biopsies in men. 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引用次数: 0
摘要
背景：在斯里兰卡，慢性肾脏病（CKD）是一项重大的临床挑战。本研究介绍了 2011-2020 年康提地区本地肾活检的组织病理学诊断结果：方法：回顾了 2011-2020 年间主要在康提教学医院进行的 5,014 例肾脏活检报告。在排除了肾移植后活检（1572 例）和无明显病理结果的活检（347 例）后，共纳入了 3095 例活检。主要组织病理学实体根据诊断进行了分组和分类，并按年龄和性别进行了分层：结果：主要组织病理学实体（所有活检）为肾小管间质性肾病（TIN）25%（760 人）、肾小球肾炎（GN）15%（467 人）、狼疮肾病 14%（429 人）、局灶节段性肾小球硬化症（FSGS）10%（297 人）和 IgA 肾病（IgAN）8%（242 人）。对于年龄≥ 15 岁的成年女性，主要的组织病理学实体为狼疮肾病 24% (325)、TIN 17% (228) 和 GN 16% (217)。对于年龄≥15 岁的成年男性，主要的组织病理学实体为 TIN 34%（449 例）、GN 14%（180 例）和 IgAN 10%（125 例）。本研究中 TIN 的比例高于规模相似的国际研究：这是迄今为止斯里兰卡报告的规模最大的肾活检研究。TIN是≥15岁成人最常见的诊断，占25%。显著的性别差异显示，TIN是男性最常见的组织病理学类型（34%），而女性则不是（17%）。以前发表过的类似研究中还没有发现 TIN 是男性肾活检的主要诊断结果。需要进一步研究在斯里兰卡观察到这些现象的可能原因：不适用。
Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka.
Background: Chronic kidney disease (CKD) is a significant clinical challenge in Sri Lanka. The present study presents histopathological diagnoses from native renal biopsies in Kandy District, 2011-2020.
Methods: Reports of 5,014 renal biopsies principally performed at Kandy Teaching Hospital over 2011-2020 were reviewed. After exclusions for post-kidney transplant biopsies (1,572) and those without evident pathology (347), 3,095 biopsies were included. The predominant histopathological entities were grouped and categorised according to diagnosis and stratified by age and sex.
Results: The main histopathological entities (all biopsies) were tubulointerstitial nephropathy (TIN) 25% (n = 760), glomerulonephritis (GN) 15% (467), lupus nephropathy 14% (429), focal segmental glomerular sclerosis (FSGS) 10% (297), and IgA nephropathy (IgAN) 8% (242). For adult women ≥ 15 years, the main histopathological entities were lupus nephropathy 24% (325), TIN 17% (228), and GN 16% (217). For adult men ≥ 15 years, the main histopathological entities were TIN 34% (449), GN 14% (180), and IgAN 10% (125). The proportion of TIN in the present study was higher than international studies of a similar size.
Conclusion: This is the largest study of renal biopsies reported from Sri Lanka to date. TIN was the most common diagnosis in adults ≥ 15 years at 25%. Notable sex differences showed TIN was the most common histopathology in men (34%) but not in women (17%). No previously published similar study of this size has found TIN as the predominant diagnosis amongst renal biopsies in men. Further research is required into the possible causes of these observations in Sri Lanka.
期刊介绍：
BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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