IGF 在免疫调节和炎症中的关键作用。

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-09-06 DOI:10.1016/j.cyto.2024.156750

Xin Wang , Lijuan Cao , Shisong Liu , Yipeng Zhou , Jiarui Zhou , Wenxuan Zhao , Shengqi Gao , Rui Liu , Yufang Shi , Changshun Shao , Jiankai Fang

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引用次数: 0

摘要

胰岛素样生长因子（IGFs）对胚胎和出生后的生长发育至关重要，可影响细胞存活、新陈代谢、肌肉生成和癌症进展。许多研究表明，类胰岛素生长因子还在炎症期间对先天性和适应性免疫系统的调节中发挥着重要作用。引人注目的是，IGFs 决定着巨噬细胞和 T 细胞的表型和功能特性。此外，IGFs 和炎性细胞因子之间的相互作用可能会在炎症期间产生保护组织的特性。在此，我们回顾了免疫细胞与 IGFs 之间对话的最新进展，尤其是免疫调节特性在炎症、癌症和自身免疫性疾病中的重要性。对 IGFs 的研究可能具有广泛的临床意义。

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The critical roles of IGFs in immune modulation and inflammation

Insulin-like growth factors (IGFs) are crucial for embryonic and postnatal growth and development, influencing cell survival, metabolism, myogenesis, and cancer progression. Many studies have demonstrated that IGFs also play prominent roles in the modulation of both innate and adaptive immune systems during inflammation. Strikingly, IGFs dictate the phenotype and functional properties of macrophages and T cells. Furthermore, the interplay between IGFs and inflammatory cytokines may generate tissue-protective properties during inflammation. Herein, we review the recent advances on the dialogue between immune cells and IGFs, especially zooming in on the significance of immunomodulatory properties in inflammatory conditions, cancer and autoimmune diseases. The investigation of IGFs may have broad clinical implications.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.