缓慢扩展的病变将小儿多发性硬化症与髓鞘少突胶质细胞糖蛋白抗体病区分开来。

IF 8.1 1区医学 Q1 CLINICAL NEUROLOGY

Annals of Neurology Pub Date : 2024-09-07 DOI:10.1002/ana.27066

Giulia Fadda MD, Brenda Banwell MD, Colm Elliott PhD, Dumitru Fetco MD, Douglas L. Arnold MD, Patrick Waters PhD, E. Ann Yeh MD, Ruth Ann Marrie MD PhD, Amit Bar-Or MD, Sridar Narayanan PhD, the Canadian Pediatric Demyelinating Disease Network

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引用次数: 0

摘要

成人多发性硬化症（MS）患者的缓慢扩展病变（SELs）预示着一种进行性病理过程。小儿多发性硬化症（POMS）或髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）是否存在缓慢扩展病变尚不清楚。我们对加拿大儿科脱髓鞘疾病研究（Canadian Pediatric Demyelinating Disease Study）招募的19名POMS患儿和14名MOGAD患儿（中位年龄分别为14.3岁和9.4岁）进行了研究：(1) 相隔 12 个月≥3 次研究扫描；(2) 在最早一次扫描中≥1 个 T2- 病变。16名POMS参与者共检测出70个SEL，MOGAD组检测出1个SEL。SEL是POMS的早期特征，基本上不是MOGAD的特征。ann neurol 2024.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Slowly Expanding Lesions Differentiate Pediatric Multiple Sclerosis from Myelin Oligodendrocyte Glycoprotein Antibody Disease

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Slowly Expanding Lesions Differentiate Pediatric Multiple Sclerosis from Myelin Oligodendrocyte Glycoprotein Antibody Disease

Slowly expanding lesions (SELs) in adults with multiple sclerosis (MS) indicate a progressive pathological process. Whether SELs are present in pediatric-onset MS (POMS) or myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unknown. We studied 19 children with POMS and 14 with MOGAD (median age 14.3 and 9.4 years, respectively) recruited to the Canadian Pediatric Demyelinating Disease Study with: (1) ≥3 research scans 12 months apart; and (2) ≥1 T2-lesions on the earliest scan. A total of 70 SELs from 16 POMS participants and 1 SEL in the MOGAD group were detected. SELs are an early feature of POMS and essentially not a feature of MOGAD. ANN NEUROL 2024;96:1086–1091

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.