基于人工智能的 MASH 组织学评分工具

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-06 DOI:10.1038/s41575-024-00987-0

Jordan Hindson

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引用次数: 0

摘要

在发表于《自然医学》（Nature Medicine）的一项研究中，研究人员报告了一种基于人工智能（AI）的数字病理学工具，用于对代谢功能障碍相关性脂肪性肝炎（MASH，以前称为非酒精性脂肪性肝炎（NASH））组织学进行评分。MASH 临床试验的入组和终点评估均基于组织学标准。该工具被称为 AIM-MASH，它对脂肪变性等级和纤维化分期的预测结果与 MASH 临床研究网络共识的分级和分期结果相当。该工具的目的是减少对试验结果解释的可变性，提高评分系统的灵敏度，并协助病理学家对 MASH 临床试验进行组织学审查。

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AI-based tool for scoring MASH histology

In a study published in Nature Medicine, researchers report an artificial intelligence (AI)-based digital pathology tool for scoring metabolic dysfunction-associated steatohepatitis (MASH; formerly known as nonalcoholic steatohepatitis (NASH)) histology. MASH clinical trial enrollment and endpoint assessment are based on histological criteria. The tool, which is termed AIM-MASH, produced predictions for steatosis grade and fibrosis stage that were comparable to consensus MASH Clinical Research Network grading and staging. The aim of the tool is to reduce variability in interpretation for trial outcomes, improve sensitivity of scoring systems and assist pathologists in histological review of clinical trials for MASH.

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.