R Benmansour, M R Tagajdid, I A Lahlou, H Oumzil, H El Hamzaoui, S Fjouji, N Doghmi, A Houba, S Elkochri, R Aabi, H Elannaz, A Laraqui, B El Mchichi, N Touil, K Ennibi, A Bouhouche
{"title":"IL-12A、IL-12B、IL-6 和 TNF 单核苷酸多态性对 COVID-19 严重性和易感性的影响。","authors":"R Benmansour, M R Tagajdid, I A Lahlou, H Oumzil, H El Hamzaoui, S Fjouji, N Doghmi, A Houba, S Elkochri, R Aabi, H Elannaz, A Laraqui, B El Mchichi, N Touil, K Ennibi, A Bouhouche","doi":"10.1177/03946320241279893","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The Coronavirus Disease 2019 (COVID-19) pandemic has led to significant global morbidity and mortality. Understanding the genetic factors that influence disease outcomes can provide critical insights into pathogenesis and potential therapeutic targets.</p><p><strong>Objective: </strong>This study aimed to investigate the potential correlation between single nucleotide polymorphisms (SNPs) in <i>Interleukin 12 Subunit Alpha (IL-12A)</i>, <i>Interleukin 12 Subunit Beta (IL-12B)</i>, <i>Interleukin 6 (IL-6)</i>, and <i>Tumor Necrosis Factor (TNF)</i> genes and the severity as well as susceptibility to COVID-19 among Moroccan patients.</p><p><strong>Patients and methods: </strong>Next-Generation sequencing (NGS) was conducted on 325 Moroccan participants, 207 patients with PCR-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and 118 controls. Among these patients, 51% presented moderate to severe symptoms requiring hospitalization, while 49% were asymptomatic or experienced mild symptoms and did not require hospitalization. Statistical analysis was performed using codominant, dominant, and recessive logistic regression models to assess correlations with the severity and susceptibility to COVID-19 infection.</p><p><strong>Results: </strong>No association was found between SNPs of <i>IL-12A</i>, <i>IL-12B</i>, <i>IL-6</i> or <i>TNF</i> and COVID-19 severity and susceptibility. However, our results unveiled a noteworthy association with <i>IL-6</i> rs2069840, which exhibited a negative correlation (OR = 0.21, 95% CI = 0.07-0.69, <i>p</i> = .006), suggesting a protective effect against SARS-CoV-2 infection.</p><p><strong>Conclusion: </strong>Polymorphisms in <i>IL-12A</i>, <i>IL-12B</i>, <i>IL-6</i>, and <i>TNF</i> genes are not correlated to the severity and susceptibility of COVID-19.</p>","PeriodicalId":48647,"journal":{"name":"International Journal of Immunopathology and Pharmacology","volume":"38 ","pages":"3946320241279893"},"PeriodicalIF":3.5000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380133/pdf/","citationCount":"0","resultStr":"{\"title\":\"Implication of IL-12A, IL-12B, IL-6, and TNF single-nucleotide polymorphisms in severity and susceptibility to COVID-19.\",\"authors\":\"R Benmansour, M R Tagajdid, I A Lahlou, H Oumzil, H El Hamzaoui, S Fjouji, N Doghmi, A Houba, S Elkochri, R Aabi, H Elannaz, A Laraqui, B El Mchichi, N Touil, K Ennibi, A Bouhouche\",\"doi\":\"10.1177/03946320241279893\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The Coronavirus Disease 2019 (COVID-19) pandemic has led to significant global morbidity and mortality. Understanding the genetic factors that influence disease outcomes can provide critical insights into pathogenesis and potential therapeutic targets.</p><p><strong>Objective: </strong>This study aimed to investigate the potential correlation between single nucleotide polymorphisms (SNPs) in <i>Interleukin 12 Subunit Alpha (IL-12A)</i>, <i>Interleukin 12 Subunit Beta (IL-12B)</i>, <i>Interleukin 6 (IL-6)</i>, and <i>Tumor Necrosis Factor (TNF)</i> genes and the severity as well as susceptibility to COVID-19 among Moroccan patients.</p><p><strong>Patients and methods: </strong>Next-Generation sequencing (NGS) was conducted on 325 Moroccan participants, 207 patients with PCR-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and 118 controls. Among these patients, 51% presented moderate to severe symptoms requiring hospitalization, while 49% were asymptomatic or experienced mild symptoms and did not require hospitalization. Statistical analysis was performed using codominant, dominant, and recessive logistic regression models to assess correlations with the severity and susceptibility to COVID-19 infection.</p><p><strong>Results: </strong>No association was found between SNPs of <i>IL-12A</i>, <i>IL-12B</i>, <i>IL-6</i> or <i>TNF</i> and COVID-19 severity and susceptibility. However, our results unveiled a noteworthy association with <i>IL-6</i> rs2069840, which exhibited a negative correlation (OR = 0.21, 95% CI = 0.07-0.69, <i>p</i> = .006), suggesting a protective effect against SARS-CoV-2 infection.</p><p><strong>Conclusion: </strong>Polymorphisms in <i>IL-12A</i>, <i>IL-12B</i>, <i>IL-6</i>, and <i>TNF</i> genes are not correlated to the severity and susceptibility of COVID-19.</p>\",\"PeriodicalId\":48647,\"journal\":{\"name\":\"International Journal of Immunopathology and Pharmacology\",\"volume\":\"38 \",\"pages\":\"3946320241279893\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380133/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Immunopathology and Pharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/03946320241279893\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Immunopathology and Pharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/03946320241279893","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Implication of IL-12A, IL-12B, IL-6, and TNF single-nucleotide polymorphisms in severity and susceptibility to COVID-19.
Background: The Coronavirus Disease 2019 (COVID-19) pandemic has led to significant global morbidity and mortality. Understanding the genetic factors that influence disease outcomes can provide critical insights into pathogenesis and potential therapeutic targets.
Objective: This study aimed to investigate the potential correlation between single nucleotide polymorphisms (SNPs) in Interleukin 12 Subunit Alpha (IL-12A), Interleukin 12 Subunit Beta (IL-12B), Interleukin 6 (IL-6), and Tumor Necrosis Factor (TNF) genes and the severity as well as susceptibility to COVID-19 among Moroccan patients.
Patients and methods: Next-Generation sequencing (NGS) was conducted on 325 Moroccan participants, 207 patients with PCR-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and 118 controls. Among these patients, 51% presented moderate to severe symptoms requiring hospitalization, while 49% were asymptomatic or experienced mild symptoms and did not require hospitalization. Statistical analysis was performed using codominant, dominant, and recessive logistic regression models to assess correlations with the severity and susceptibility to COVID-19 infection.
Results: No association was found between SNPs of IL-12A, IL-12B, IL-6 or TNF and COVID-19 severity and susceptibility. However, our results unveiled a noteworthy association with IL-6 rs2069840, which exhibited a negative correlation (OR = 0.21, 95% CI = 0.07-0.69, p = .006), suggesting a protective effect against SARS-CoV-2 infection.
Conclusion: Polymorphisms in IL-12A, IL-12B, IL-6, and TNF genes are not correlated to the severity and susceptibility of COVID-19.
期刊介绍：
International Journal of Immunopathology and Pharmacology is an Open Access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. The intention is that the journal should reflect both the experimental and clinical aspects of immunology as well as advances in the understanding of the pathology and pharmacology of the immune system.
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