无冠状动脉钙化者发生中风的预测因素:多种族动脉粥样硬化研究》、《杰克逊心脏研究》和《弗雷明汉心脏研究》的汇总队列分析。

IF 3 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Aliza Hussain, Michelle C Johansen, Michael J Blaha, Mouaz H Al-Mallah, Miguel Cainzos-Achirica, Vijay Nambi, Jerome I Rotter, Xiuqing Guo, Jie Yao, Stephen S Rich, Jaideep Patel, John W McEvoy, Khurram Nasir, Rebecca Gottesman, Roger S Blumenthal, Christie M Ballantyne, Salim S Virani, Mahmoud Al Rifai
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引用次数: 0

摘要

导言:无冠状动脉钙化(CAC = 0)与中风事件的低风险相关;然而,CAC = 0 患者中发生中风的预测因素尚不清楚:方法:从三个前瞻性队列(多种族动脉粥样硬化研究、杰克逊心脏研究和弗雷明汉心脏研究)中汇集个人参与者水平的数据。采用多变量调整的 Cox 比例危险模型研究基线时无临床动脉粥样硬化性心血管疾病、CAC = 0 的个体的心血管危险因素与判定卒中事件之间的关系:在 6180 名参与者(平均年龄 53 [SD 11] 岁,62% 为女性,44% 为白人,36% 为黑人,20% 为其他人群)中,在中位数(IQR)为 15(12-16)年的随访期间,共发生 122 例中风(95 例缺血性中风,27 例出血性中风),总体未调整事件发生率为 2.0‰。经多变量调整后,与总体中风相关的风险因素包括(危险比 [95% CI])收缩压 (SBP):每增加 10 mmHg 为 1.19(1.05-1.36),颈动脉内膜中层厚度 (CIMT):每增加 10 mmHg 为 1.21(1.04-1.36):每增加 0.1 毫米:1.21(1.04-1.42)。目前吸烟:2.68 (1.11-6.50)、SBP:每增加 10 mmHg 增加 1.23 (1.06-1.42)、CIMT:每增加 0.1 mm 增加 1.25 (1.04-1.49)与缺血性中风相关,而 C 反应蛋白与出血性中风风险相关(0.49, 0.25-0.93):结论:在 CAC = 0 的大型人群中,中风发生率较低(每千人年 2.0 例),且与可改变的风险因素有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictors of incident stroke among individuals without coronary artery calcification: A pooled cohort analysis from the Multi-Ethnic Study of Atherosclerosis, Jackson Heart Study, and Framingham Heart Study.

Introduction: The absence of coronary artery calcium (CAC = 0) is associated with low risk of stroke events; however, predictors of incident stroke among those with CAC = 0 are not known.

Methods: Individual participant-level data were pooled from three prospective cohorts (Multi-Ethnic Study of Atherosclerosis, Jackson Heart Study, and Framingham Heart Study). Multivariable-adjusted Cox proportional hazards models were used to study the association between cardiovascular risk factors and incident adjudicated stroke among individuals with CAC = 0 who were free of clinical atherosclerotic cardiovascular disease at baseline.

Results: Among 6180 participants (mean age 53 [SD 11] years, 62% women, and 44% White, 36% Black, and 20% other individuals), over a median (IQR) follow up of 15 (12-16) years, there were 122 strokes (95 ischemic, 27 hemorrhagic) with an overall unadjusted event rate of 2.0 per 1000 person-years. After multivariable adjustment, risk factors associated with overall stroke included (hazard ratio [95% CI]) systolic blood pressure (SBP): 1.19 (1.05-1.36) per 10-mmHg increase and carotid intima-media thickness (CIMT): 1.21 (1.04-1.42) per 0.1-mm increment. Current cigarette smoking: 2.68 (1.11-6.50), SBP: 1.23 (1.06-1.42) per 10-mmHg increase, and CIMT: 1.25 (1.04-1.49) per 0.1-mm increment were associated with ischemic stroke, whereas C-reactive protein was associated with hemorrhagic stroke risk (0.49, 0.25-0.93).

Conclusion: In a large cohort of individuals with CAC = 0, the rate for incident stroke was low (2.0 per 1000-person years) and was associated with modifiable risk factors.

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来源期刊
Vascular Medicine
Vascular Medicine 医学-外周血管病
CiteScore
5.70
自引率
5.70%
发文量
158
审稿时长
>12 weeks
期刊介绍: The premier, ISI-ranked journal of vascular medicine. Integrates the latest research in vascular biology with advancements for the practice of vascular medicine and vascular surgery. It features original research and reviews on vascular biology, epidemiology, diagnosis, medical treatment and interventions for vascular disease. A member of the Committee on Publication Ethics (COPE)
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