肾移植患者使用超极化[1-13C]丙酮酸核磁共振成像进行代谢成像的初步经验。

IF 3.3 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Xiaoxi Liu, Ying-Chieh Lai, Di Cui, Shiang-Cheng Kung, Meyeon Park, Zoltan Laszik, Peder E Z Larson, Zhen J Wang
{"title":"肾移植患者使用超极化[1-13C]丙酮酸核磁共振成像进行代谢成像的初步经验。","authors":"Xiaoxi Liu, Ying-Chieh Lai, Di Cui, Shiang-Cheng Kung, Meyeon Park, Zoltan Laszik, Peder E Z Larson, Zhen J Wang","doi":"10.1002/jmri.29580","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Kidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage.</p><p><strong>Purpose: </strong>To investigate the feasibility of hyperpolarized (HP) [1-<sup>13</sup>C]pyruvate MRI for assessing kidney allograft metabolism.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Six participants (mean age, 45.2 ± 12.4 years, two females) scheduled for kidney allograft biopsy and five patients (mean age, 59.6 ± 10.4 years, two females) with renal cell carcinoma (RCC).</p><p><strong>Field strength/sequence: </strong>Three Tesla, T2-weighted fast spin echo, multi-echo gradient echo, single shot diffusion-weighted echo-planar imaging, and time-resolved HP <sup>13</sup>C metabolite-selective imaging.</p><p><strong>Assessment: </strong>Five of the six kidney allograft participants underwent biopsy after MRI. Estimated glomerular filtration rate (eGFR) and urine protein-to-creatine ratio (uPCR) were collected within 4 weeks of MRI. Kidney metabolism was quantified from HP [1-<sup>13</sup>C]pyruvate MRI using the lactate-to-pyruvate ratio in allograft kidneys and non-tumor bearing kidneys from RCC patients.</p><p><strong>Statistical tests: </strong>Descriptive statistics (mean ± SD).</p><p><strong>Results: </strong>Biopsy was performed a mean of 9 days (range 5-19 days) after HP [1-<sup>13</sup>C]pyruvate MRI. Three biopsies were normal, one showed low-grade fibrosis and one showed moderate microvascular inflammation. All had stable functioning allografts with eGFR >60 mL/min/1.73 m<sup>2</sup> and normal uPCR. One participant who did not undergo biopsy had reduced eGFR of 49 mL/min/1.73 m<sup>2</sup> and elevated uPCR. The mean lactate-to-pyruvate ratio was 0.373 in participants with normal findings (N = 3) and 0.552 in participants with abnormal findings (N = 2). The lactate-to-pyruvate ratio was highest (0.847) in the participant with reduced eGFR and elevated uPRC. Native non-tumor bearing kidneys had a mean lactate-to-pyruvate ratio of 0.309.</p><p><strong>Data conclusion: </strong>Stable allografts with normal findings at biopsy showed lactate-to-pyruvate ratios similar to native non-tumor bearing kidneys, whereas allografts with abnormal findings showed higher lactate-to-pyruvate ratios.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Initial Experience of Metabolic Imaging With Hyperpolarized [1-<sup>13</sup>C]pyruvate MRI in Kidney Transplant Patients.\",\"authors\":\"Xiaoxi Liu, Ying-Chieh Lai, Di Cui, Shiang-Cheng Kung, Meyeon Park, Zoltan Laszik, Peder E Z Larson, Zhen J Wang\",\"doi\":\"10.1002/jmri.29580\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Kidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage.</p><p><strong>Purpose: </strong>To investigate the feasibility of hyperpolarized (HP) [1-<sup>13</sup>C]pyruvate MRI for assessing kidney allograft metabolism.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Six participants (mean age, 45.2 ± 12.4 years, two females) scheduled for kidney allograft biopsy and five patients (mean age, 59.6 ± 10.4 years, two females) with renal cell carcinoma (RCC).</p><p><strong>Field strength/sequence: </strong>Three Tesla, T2-weighted fast spin echo, multi-echo gradient echo, single shot diffusion-weighted echo-planar imaging, and time-resolved HP <sup>13</sup>C metabolite-selective imaging.</p><p><strong>Assessment: </strong>Five of the six kidney allograft participants underwent biopsy after MRI. Estimated glomerular filtration rate (eGFR) and urine protein-to-creatine ratio (uPCR) were collected within 4 weeks of MRI. Kidney metabolism was quantified from HP [1-<sup>13</sup>C]pyruvate MRI using the lactate-to-pyruvate ratio in allograft kidneys and non-tumor bearing kidneys from RCC patients.</p><p><strong>Statistical tests: </strong>Descriptive statistics (mean ± SD).</p><p><strong>Results: </strong>Biopsy was performed a mean of 9 days (range 5-19 days) after HP [1-<sup>13</sup>C]pyruvate MRI. Three biopsies were normal, one showed low-grade fibrosis and one showed moderate microvascular inflammation. All had stable functioning allografts with eGFR >60 mL/min/1.73 m<sup>2</sup> and normal uPCR. One participant who did not undergo biopsy had reduced eGFR of 49 mL/min/1.73 m<sup>2</sup> and elevated uPCR. The mean lactate-to-pyruvate ratio was 0.373 in participants with normal findings (N = 3) and 0.552 in participants with abnormal findings (N = 2). The lactate-to-pyruvate ratio was highest (0.847) in the participant with reduced eGFR and elevated uPRC. Native non-tumor bearing kidneys had a mean lactate-to-pyruvate ratio of 0.309.</p><p><strong>Data conclusion: </strong>Stable allografts with normal findings at biopsy showed lactate-to-pyruvate ratios similar to native non-tumor bearing kidneys, whereas allografts with abnormal findings showed higher lactate-to-pyruvate ratios.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>\",\"PeriodicalId\":16140,\"journal\":{\"name\":\"Journal of Magnetic Resonance Imaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.29580\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.29580","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

摘要

背景:肾移植是终末期肾病患者的首选治疗方法。目的:研究超极化(HP)[1-13C]丙酮酸核磁共振成像评估肾移植新陈代谢的可行性:研究类型:前瞻性:六名计划进行肾脏异体移植活检的参与者(平均年龄 45.2 ± 12.4 岁,两名女性)和五名肾细胞癌(RCC)患者(平均年龄 59.6 ± 10.4 岁,两名女性):三特斯拉、T2加权快速自旋回波、多回波梯度回波、单次弥散加权回声平面成像和时间分辨HP 13C代谢物选择性成像:六名肾移植参与者中有五人在核磁共振成像后进行了活组织检查。在核磁共振成像后 4 周内收集了估计肾小球滤过率(eGFR)和尿蛋白肌酸比(uPCR)。肾脏新陈代谢是通过HP [1-13C]丙酮酸核磁共振成像,利用RCC患者异体移植肾和无肿瘤肾脏的乳酸与丙酮酸比率进行量化的:结果:活检平均在 HP [1-13C] 丙酮酸 MRI 后 9 天(5-19 天)进行。三例活检结果正常,一例显示低度纤维化,一例显示中度微血管炎症。所有受试者的异体移植物功能稳定,eGFR >60 mL/min/1.73 m2,uPCR 正常。一名未进行活组织检查的参与者的 eGFR 降低至 49 mL/min/1.73 m2,uPCR 升高。检查结果正常的参与者(3 人)的平均乳酸丙酮酸比值为 0.373,检查结果异常的参与者(2 人)的平均乳酸丙酮酸比值为 0.552。eGFR降低和uPRC升高的参与者的乳酸丙酮酸比值最高(0.847)。数据结论:数据结论:活检结果正常的稳定异体移植肾的乳酸丙酮酸比值与原生非肿瘤性肾相似,而活检结果异常的异体移植肾的乳酸丙酮酸比值更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Initial Experience of Metabolic Imaging With Hyperpolarized [1-13C]pyruvate MRI in Kidney Transplant Patients.

Background: Kidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage.

Purpose: To investigate the feasibility of hyperpolarized (HP) [1-13C]pyruvate MRI for assessing kidney allograft metabolism.

Study type: Prospective.

Subjects: Six participants (mean age, 45.2 ± 12.4 years, two females) scheduled for kidney allograft biopsy and five patients (mean age, 59.6 ± 10.4 years, two females) with renal cell carcinoma (RCC).

Field strength/sequence: Three Tesla, T2-weighted fast spin echo, multi-echo gradient echo, single shot diffusion-weighted echo-planar imaging, and time-resolved HP 13C metabolite-selective imaging.

Assessment: Five of the six kidney allograft participants underwent biopsy after MRI. Estimated glomerular filtration rate (eGFR) and urine protein-to-creatine ratio (uPCR) were collected within 4 weeks of MRI. Kidney metabolism was quantified from HP [1-13C]pyruvate MRI using the lactate-to-pyruvate ratio in allograft kidneys and non-tumor bearing kidneys from RCC patients.

Statistical tests: Descriptive statistics (mean ± SD).

Results: Biopsy was performed a mean of 9 days (range 5-19 days) after HP [1-13C]pyruvate MRI. Three biopsies were normal, one showed low-grade fibrosis and one showed moderate microvascular inflammation. All had stable functioning allografts with eGFR >60 mL/min/1.73 m2 and normal uPCR. One participant who did not undergo biopsy had reduced eGFR of 49 mL/min/1.73 m2 and elevated uPCR. The mean lactate-to-pyruvate ratio was 0.373 in participants with normal findings (N = 3) and 0.552 in participants with abnormal findings (N = 2). The lactate-to-pyruvate ratio was highest (0.847) in the participant with reduced eGFR and elevated uPRC. Native non-tumor bearing kidneys had a mean lactate-to-pyruvate ratio of 0.309.

Data conclusion: Stable allografts with normal findings at biopsy showed lactate-to-pyruvate ratios similar to native non-tumor bearing kidneys, whereas allografts with abnormal findings showed higher lactate-to-pyruvate ratios.

Evidence level: 2 TECHNICAL EFFICACY: Stage 2.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信