关注用于识别轻度认知障碍的血浆生物标志物，加强阿尔茨海默氏症的诊断和护理。

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2024-09-02 DOI:10.3233/JAD-240724

Remy Cardoso, Charlotte E Teunissen, Catarina Resende Oliveira

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引用次数: 0

摘要

能准确识别轻度认知障碍（MCI）的生物标记物对阿尔茨海默病（AD）的管理和治疗具有重要意义。另一方面，与常见的脑脊液生物标志物相比，基于血液的生物标志物不仅更实用，而且创伤更小。在《阿尔茨海默病杂志》（Journal of Alzheimer's Disease）上发表的报告中，Wang 及其合作者发现了 67 种上调和 220 种下调的长非编码 RNA（lncRNA）。他们进一步证明，其中 4 个 lncRNAs 可以区分 MCI 和认知健康的个体。这些lncRNA除了可作为MCI诊断的潜在生物标志物外，还能提供有关AD病理细胞机制的更多信息。

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Enhancing Alzheimer's Disease Diagnosis and Care by Focusing on Plasma Biomarkers for Identifying Mild Cognitive Impairment.

Biomarkers that accurately identify mild cognitive impairment (MCI) are of greater importance for Alzheimer's disease (AD) management and treatment. On the other hand, blood-based biomarkers are not only more practical but also less invasive than the common cerebrospinal fluid biomarkers. In their report in the Journal of Alzheimer's Disease, Wang and collaborators identified 67 upregulated and 220 downregulated long noncoding RNAs (lncRNAs). They further demonstrated that 4 of these lncRNAs could discriminate MCI from cognitively healthy individuals. Apart from their significance as potential biomarkers for MCI diagnosis, these lncRNAs can offer additional information on the cellular mechanisms of AD pathology.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.