Charles Nkansah, Felix Osei-Boakye, Gabriel Abbam, Samuel K. Appiah, Samira Daud, Bright Boakye, Samsiyatu Abdulai, Madina Ahmed, Theophilus B. Antwi, Birago Boateng, Miigbat P. Libatin, Alexander S. Mensah, Mary K. Missah, Richard V. Duneeh, Ashiya Haruna, Stephany Adda, Pagnaa G. Abdul-Rauf, Zacharia A. Ofori, George B. Fosu, Sandra Segnitome, Isaac Adjei, Emmanuel Appiah-Kubi, Moses Banyeh, Charles A. Derigubah, Muniru M. Tanko, Ejike F. Chukwurah
{"title":"促炎和抗炎细胞因子介导疟疾感染儿童重度贫血的发展：前瞻性研究","authors":"Charles Nkansah, Felix Osei-Boakye, Gabriel Abbam, Samuel K. Appiah, Samira Daud, Bright Boakye, Samsiyatu Abdulai, Madina Ahmed, Theophilus B. Antwi, Birago Boateng, Miigbat P. Libatin, Alexander S. Mensah, Mary K. Missah, Richard V. Duneeh, Ashiya Haruna, Stephany Adda, Pagnaa G. Abdul-Rauf, Zacharia A. Ofori, George B. Fosu, Sandra Segnitome, Isaac Adjei, Emmanuel Appiah-Kubi, Moses Banyeh, Charles A. Derigubah, Muniru M. Tanko, Ejike F. Chukwurah","doi":"10.1002/iid3.70013","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Severe <i>Plasmodium falciparum</i> malarial anemia is still the principal cause of death in children in underdeveloped countries. An imbalance between proinflammatory and anti-inflammatory cytokines is associated with malaria progression. This study evaluated circulating levels of selected inflammatory cytokines among malaria-infected children in Ghana.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This case-control study was conducted at Tamale Teaching Hospital, Ghana. One hundred and twenty children with malaria and 60 controls, aged 12−144 months were selected from April to July, 2023 for the study. Malaria was diagnosed through microscopy, full blood count was measured using hematology analyzer, and cytokines were measured using enzyme-linked immunosorbent assay.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Malaria-infected children had higher tumor necrosis factor alpha (TNF-α) (<i>p</i> < .001), interferon-gamma (IFN-ɣ) (<i>p</i> < .001), interleukin (IL)-1β (<i>p</i> < .001), IL-6 (<i>p</i> < .001), granulocyte macrophage-colony stimulating factor (GM-CSF) (<i>p</i> < .001), and IL-10 (<i>p</i> < .001) levels than controls. Participants with high parasitemia had raised TNF-α (<i>p</i> < .001), IFN-ɣ (<i>p</i> < .001), IL-1β (<i>p</i> < .001), IL-6 (<i>p</i> < .001), GM-CSF (<i>p</i> < .001), and IL-10 (<i>p</i> < .001), but reduced IL-3 (<i>p</i> < .001) and TGF-β (<i>p</i> < .001) than those with low parasitemia. Severe malarial anemic children had elevated TNF-α (<i>p</i> < .001), IFN-ɣ (<i>p</i> < .001), IL-1β (<i>p</i> < .001), IL-6 (<i>p</i> < .001), GM-CSF (<i>p</i> < .001), and IL-10 (<i>p</i> < .001), but lower IL-3 (<i>p</i> < .001) and TGF-β (<i>p</i> < .001) than those with uncomplicated malaria.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Parasite density was the principal predictor of the cytokine levels, as parasitemia positively associated with IL-10, GM-CSF, IL-6, IL-1β, IFN-ɣ, and TNF-α, but negatively associated with IL-3 and TGF-β. Malaria is associated with enhanced secretion of pro- and anti-inflammatory cytokines in Ghanaian children. Inflammatory cytokines may be involved in the development of severe malarial anemia in children. However, IL-3 and TGF-β may offer protection against severe malarial anemia.</p>\n </section>\n </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70013","citationCount":"0","resultStr":"{\"title\":\"Pro- and anti-inflammatory cytokines mediate the progression of severe anemia in malaria-infected children: A prospective study\",\"authors\":\"Charles Nkansah, Felix Osei-Boakye, Gabriel Abbam, Samuel K. Appiah, Samira Daud, Bright Boakye, Samsiyatu Abdulai, Madina Ahmed, Theophilus B. Antwi, Birago Boateng, Miigbat P. Libatin, Alexander S. Mensah, Mary K. Missah, Richard V. Duneeh, Ashiya Haruna, Stephany Adda, Pagnaa G. Abdul-Rauf, Zacharia A. Ofori, George B. Fosu, Sandra Segnitome, Isaac Adjei, Emmanuel Appiah-Kubi, Moses Banyeh, Charles A. Derigubah, Muniru M. Tanko, Ejike F. Chukwurah\",\"doi\":\"10.1002/iid3.70013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Severe <i>Plasmodium falciparum</i> malarial anemia is still the principal cause of death in children in underdeveloped countries. An imbalance between proinflammatory and anti-inflammatory cytokines is associated with malaria progression. This study evaluated circulating levels of selected inflammatory cytokines among malaria-infected children in Ghana.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This case-control study was conducted at Tamale Teaching Hospital, Ghana. One hundred and twenty children with malaria and 60 controls, aged 12−144 months were selected from April to July, 2023 for the study. Malaria was diagnosed through microscopy, full blood count was measured using hematology analyzer, and cytokines were measured using enzyme-linked immunosorbent assay.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Malaria-infected children had higher tumor necrosis factor alpha (TNF-α) (<i>p</i> < .001), interferon-gamma (IFN-ɣ) (<i>p</i> < .001), interleukin (IL)-1β (<i>p</i> < .001), IL-6 (<i>p</i> < .001), granulocyte macrophage-colony stimulating factor (GM-CSF) (<i>p</i> < .001), and IL-10 (<i>p</i> < .001) levels than controls. Participants with high parasitemia had raised TNF-α (<i>p</i> < .001), IFN-ɣ (<i>p</i> < .001), IL-1β (<i>p</i> < .001), IL-6 (<i>p</i> < .001), GM-CSF (<i>p</i> < .001), and IL-10 (<i>p</i> < .001), but reduced IL-3 (<i>p</i> < .001) and TGF-β (<i>p</i> < .001) than those with low parasitemia. Severe malarial anemic children had elevated TNF-α (<i>p</i> < .001), IFN-ɣ (<i>p</i> < .001), IL-1β (<i>p</i> < .001), IL-6 (<i>p</i> < .001), GM-CSF (<i>p</i> < .001), and IL-10 (<i>p</i> < .001), but lower IL-3 (<i>p</i> < .001) and TGF-β (<i>p</i> < .001) than those with uncomplicated malaria.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Parasite density was the principal predictor of the cytokine levels, as parasitemia positively associated with IL-10, GM-CSF, IL-6, IL-1β, IFN-ɣ, and TNF-α, but negatively associated with IL-3 and TGF-β. Malaria is associated with enhanced secretion of pro- and anti-inflammatory cytokines in Ghanaian children. Inflammatory cytokines may be involved in the development of severe malarial anemia in children. However, IL-3 and TGF-β may offer protection against severe malarial anemia.</p>\\n </section>\\n </div>\",\"PeriodicalId\":13289,\"journal\":{\"name\":\"Immunity, Inflammation and Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70013\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunity, Inflammation and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/iid3.70013\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunity, Inflammation and Disease","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iid3.70013","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Pro- and anti-inflammatory cytokines mediate the progression of severe anemia in malaria-infected children: A prospective study
Background
Severe Plasmodium falciparum malarial anemia is still the principal cause of death in children in underdeveloped countries. An imbalance between proinflammatory and anti-inflammatory cytokines is associated with malaria progression. This study evaluated circulating levels of selected inflammatory cytokines among malaria-infected children in Ghana.
Methods
This case-control study was conducted at Tamale Teaching Hospital, Ghana. One hundred and twenty children with malaria and 60 controls, aged 12−144 months were selected from April to July, 2023 for the study. Malaria was diagnosed through microscopy, full blood count was measured using hematology analyzer, and cytokines were measured using enzyme-linked immunosorbent assay.
Results
Malaria-infected children had higher tumor necrosis factor alpha (TNF-α) (p < .001), interferon-gamma (IFN-ɣ) (p < .001), interleukin (IL)-1β (p < .001), IL-6 (p < .001), granulocyte macrophage-colony stimulating factor (GM-CSF) (p < .001), and IL-10 (p < .001) levels than controls. Participants with high parasitemia had raised TNF-α (p < .001), IFN-ɣ (p < .001), IL-1β (p < .001), IL-6 (p < .001), GM-CSF (p < .001), and IL-10 (p < .001), but reduced IL-3 (p < .001) and TGF-β (p < .001) than those with low parasitemia. Severe malarial anemic children had elevated TNF-α (p < .001), IFN-ɣ (p < .001), IL-1β (p < .001), IL-6 (p < .001), GM-CSF (p < .001), and IL-10 (p < .001), but lower IL-3 (p < .001) and TGF-β (p < .001) than those with uncomplicated malaria.
Conclusion
Parasite density was the principal predictor of the cytokine levels, as parasitemia positively associated with IL-10, GM-CSF, IL-6, IL-1β, IFN-ɣ, and TNF-α, but negatively associated with IL-3 and TGF-β. Malaria is associated with enhanced secretion of pro- and anti-inflammatory cytokines in Ghanaian children. Inflammatory cytokines may be involved in the development of severe malarial anemia in children. However, IL-3 and TGF-β may offer protection against severe malarial anemia.
期刊介绍：
Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including:
• cellular and molecular immunology
• clinical immunology
• allergy
• immunochemistry
• immunogenetics
• immune signalling
• immune development
• imaging
• mathematical modelling
• autoimmunity
• transplantation immunology
• cancer immunology
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