Chelsea Anderson, Jeannette T Bensen, Emma H Allott, Patricia V Basta, Debra E Irwin, Adrian Gerstel, Laura Farnan, Hung-Jui Tan, Erin E Kent, Tzy-Mey Kuo, Christopher D Baggett, Andrew F Olshan, H Shelton Earp, Hazel B Nichols
{"title":"北卡罗来纳大学癌症幸存者队列：幸存者合作研究资源。","authors":"Chelsea Anderson, Jeannette T Bensen, Emma H Allott, Patricia V Basta, Debra E Irwin, Adrian Gerstel, Laura Farnan, Hung-Jui Tan, Erin E Kent, Tzy-Mey Kuo, Christopher D Baggett, Andrew F Olshan, H Shelton Earp, Hazel B Nichols","doi":"10.1158/1055-9965.EPI-24-0794","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Rapid growth in the number of U.S. cancer survivors drives the need for ongoing research efforts to improve outcomes and experiences after cancer. Here we describe the University of North Carolina (UNC) Cancer Survivorship Cohort, a medical center-based cohort of adults with cancer that integrates medical record-abstracted cancer information, patient-reported outcomes, and biologic specimens.</p><p><strong>Methods: </strong>Participants ages 18+ were recruited from UNC oncology clinics between April 2010 and August 2016. After enrollment, participants completed questionnaires on a range of topics including demographics, health history, health care access and utilization, quality of life, and symptoms. Blood samples and tumor tissue specimens were collected and processed by study staff, and cancer characteristics and other clinical data were abstracted from electronic medical records. Participants consented to recontact for future studies and linkage of their data with other data resources.</p><p><strong>Results: </strong>In total, 3,999 participants with a cancer diagnosis were enrolled in the cohort. The most common cancer types among those enrolled included breast (N=866), uterine (N=458), colorectal (N=300), prostate (N=296), and head and neck (N=248). Blood specimens were collected for 3,027 (76%). Additional participants without cancer (N=1,299) were also enrolled, and the majority (62%) provided biospecimen samples.</p><p><strong>Conclusions: </strong>We encourage wide collaboration with investigators across institutions seeking to advance research in cancer survivorship. Procedures are in place to support proposals for use of existing or linked data and for proposals that require participant recontact or analysis of biospecimens.</p><p><strong>Impact: </strong>The UNC Cancer Survivorship Cohort is a unique resource for cancer survivorship research.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The University of North Carolina Cancer Survivorship Cohort: A resource for collaborative survivorship research.\",\"authors\":\"Chelsea Anderson, Jeannette T Bensen, Emma H Allott, Patricia V Basta, Debra E Irwin, Adrian Gerstel, Laura Farnan, Hung-Jui Tan, Erin E Kent, Tzy-Mey Kuo, Christopher D Baggett, Andrew F Olshan, H Shelton Earp, Hazel B Nichols\",\"doi\":\"10.1158/1055-9965.EPI-24-0794\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Rapid growth in the number of U.S. cancer survivors drives the need for ongoing research efforts to improve outcomes and experiences after cancer. Here we describe the University of North Carolina (UNC) Cancer Survivorship Cohort, a medical center-based cohort of adults with cancer that integrates medical record-abstracted cancer information, patient-reported outcomes, and biologic specimens.</p><p><strong>Methods: </strong>Participants ages 18+ were recruited from UNC oncology clinics between April 2010 and August 2016. After enrollment, participants completed questionnaires on a range of topics including demographics, health history, health care access and utilization, quality of life, and symptoms. Blood samples and tumor tissue specimens were collected and processed by study staff, and cancer characteristics and other clinical data were abstracted from electronic medical records. Participants consented to recontact for future studies and linkage of their data with other data resources.</p><p><strong>Results: </strong>In total, 3,999 participants with a cancer diagnosis were enrolled in the cohort. The most common cancer types among those enrolled included breast (N=866), uterine (N=458), colorectal (N=300), prostate (N=296), and head and neck (N=248). Blood specimens were collected for 3,027 (76%). Additional participants without cancer (N=1,299) were also enrolled, and the majority (62%) provided biospecimen samples.</p><p><strong>Conclusions: </strong>We encourage wide collaboration with investigators across institutions seeking to advance research in cancer survivorship. 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The University of North Carolina Cancer Survivorship Cohort: A resource for collaborative survivorship research.
Background: Rapid growth in the number of U.S. cancer survivors drives the need for ongoing research efforts to improve outcomes and experiences after cancer. Here we describe the University of North Carolina (UNC) Cancer Survivorship Cohort, a medical center-based cohort of adults with cancer that integrates medical record-abstracted cancer information, patient-reported outcomes, and biologic specimens.
Methods: Participants ages 18+ were recruited from UNC oncology clinics between April 2010 and August 2016. After enrollment, participants completed questionnaires on a range of topics including demographics, health history, health care access and utilization, quality of life, and symptoms. Blood samples and tumor tissue specimens were collected and processed by study staff, and cancer characteristics and other clinical data were abstracted from electronic medical records. Participants consented to recontact for future studies and linkage of their data with other data resources.
Results: In total, 3,999 participants with a cancer diagnosis were enrolled in the cohort. The most common cancer types among those enrolled included breast (N=866), uterine (N=458), colorectal (N=300), prostate (N=296), and head and neck (N=248). Blood specimens were collected for 3,027 (76%). Additional participants without cancer (N=1,299) were also enrolled, and the majority (62%) provided biospecimen samples.
Conclusions: We encourage wide collaboration with investigators across institutions seeking to advance research in cancer survivorship. Procedures are in place to support proposals for use of existing or linked data and for proposals that require participant recontact or analysis of biospecimens.
Impact: The UNC Cancer Survivorship Cohort is a unique resource for cancer survivorship research.
期刊介绍：
Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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