{"title":"评估新诊断出的 1 型糖尿病患儿的脉络膜结构。","authors":"Serdar Bilici, Tuba Gultekin Erol, Meliha Esra Bilici, Silay Canturk Ugurbas, Suat Hayri Ugurbas","doi":"10.14744/bej.2024.36036","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to evaluate the subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) in children with newly diagnosed type 1 diabetes mellitus (T1DM).</p><p><strong>Methods: </strong>A total of 80 children (40 with T1DM and 40 healthy controls) were included in this cross-sectional study. Enhanced depth imaging optical coherence tomography (EDI-OCT) images of all participants were analyzed. The SFCT, total choroidal area (TCA), luminal area (LA), stromal area (SA), and CVI measurements were obtained from EDI-OCT images and compared between groups. The effects of HbA1c, fasting plasma glucose, and axial length measurements on choroidal measurements were investigated.</p><p><strong>Results: </strong>There was no significant difference between the groups according to TCA (0.84 [0.57-1.26] vs. 0.88 [0.65-1.16] mm<sup>2</sup>, p=0.745), LA (0.55 [0.41-0.79] vs. 0.59 [0.43-0.74] mm<sup>2</sup>, p=0.745), SA (0.27 [0.15-0.47] vs. 0.28 [0.15-0.47] mm<sup>2</sup>, p=0.935), and CVI (68.03 [66.5-70.5] vs. 67.75 [66.2-69.5] %, p=0.794), respectively. However, T1DM patients had thinner SFCT compared to control subjects (309.0 [327-489] and 398.5 [219-491], p<0.044). No correlation was found between HbA1c, fasting plasma glucose, axial length measurements, and SFCT, TCA, LA, SA, or CVI.</p><p><strong>Conclusion: </strong>Children with newly diagnosed T1DM have thinner SCFT in comparison to healthy children, however, no significant difference in CVI was observed between the groups. Long-term follow-up should be used to confirm the impact of the DM duration on CVI.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"9 3","pages":"144-148"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372406/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Choroidal Structures in Children with Newly Diagnosed Type-1 Diabetes Mellitus.\",\"authors\":\"Serdar Bilici, Tuba Gultekin Erol, Meliha Esra Bilici, Silay Canturk Ugurbas, Suat Hayri Ugurbas\",\"doi\":\"10.14744/bej.2024.36036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The objective of this study was to evaluate the subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) in children with newly diagnosed type 1 diabetes mellitus (T1DM).</p><p><strong>Methods: </strong>A total of 80 children (40 with T1DM and 40 healthy controls) were included in this cross-sectional study. Enhanced depth imaging optical coherence tomography (EDI-OCT) images of all participants were analyzed. The SFCT, total choroidal area (TCA), luminal area (LA), stromal area (SA), and CVI measurements were obtained from EDI-OCT images and compared between groups. The effects of HbA1c, fasting plasma glucose, and axial length measurements on choroidal measurements were investigated.</p><p><strong>Results: </strong>There was no significant difference between the groups according to TCA (0.84 [0.57-1.26] vs. 0.88 [0.65-1.16] mm<sup>2</sup>, p=0.745), LA (0.55 [0.41-0.79] vs. 0.59 [0.43-0.74] mm<sup>2</sup>, p=0.745), SA (0.27 [0.15-0.47] vs. 0.28 [0.15-0.47] mm<sup>2</sup>, p=0.935), and CVI (68.03 [66.5-70.5] vs. 67.75 [66.2-69.5] %, p=0.794), respectively. However, T1DM patients had thinner SFCT compared to control subjects (309.0 [327-489] and 398.5 [219-491], p<0.044). No correlation was found between HbA1c, fasting plasma glucose, axial length measurements, and SFCT, TCA, LA, SA, or CVI.</p><p><strong>Conclusion: </strong>Children with newly diagnosed T1DM have thinner SCFT in comparison to healthy children, however, no significant difference in CVI was observed between the groups. Long-term follow-up should be used to confirm the impact of the DM duration on CVI.</p>\",\"PeriodicalId\":8740,\"journal\":{\"name\":\"Beyoglu Eye Journal\",\"volume\":\"9 3\",\"pages\":\"144-148\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372406/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Beyoglu Eye Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14744/bej.2024.36036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Beyoglu Eye Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14744/bej.2024.36036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of Choroidal Structures in Children with Newly Diagnosed Type-1 Diabetes Mellitus.
Objectives: The objective of this study was to evaluate the subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) in children with newly diagnosed type 1 diabetes mellitus (T1DM).
Methods: A total of 80 children (40 with T1DM and 40 healthy controls) were included in this cross-sectional study. Enhanced depth imaging optical coherence tomography (EDI-OCT) images of all participants were analyzed. The SFCT, total choroidal area (TCA), luminal area (LA), stromal area (SA), and CVI measurements were obtained from EDI-OCT images and compared between groups. The effects of HbA1c, fasting plasma glucose, and axial length measurements on choroidal measurements were investigated.
Results: There was no significant difference between the groups according to TCA (0.84 [0.57-1.26] vs. 0.88 [0.65-1.16] mm2, p=0.745), LA (0.55 [0.41-0.79] vs. 0.59 [0.43-0.74] mm2, p=0.745), SA (0.27 [0.15-0.47] vs. 0.28 [0.15-0.47] mm2, p=0.935), and CVI (68.03 [66.5-70.5] vs. 67.75 [66.2-69.5] %, p=0.794), respectively. However, T1DM patients had thinner SFCT compared to control subjects (309.0 [327-489] and 398.5 [219-491], p<0.044). No correlation was found between HbA1c, fasting plasma glucose, axial length measurements, and SFCT, TCA, LA, SA, or CVI.
Conclusion: Children with newly diagnosed T1DM have thinner SCFT in comparison to healthy children, however, no significant difference in CVI was observed between the groups. Long-term follow-up should be used to confirm the impact of the DM duration on CVI.
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