中国北方家庭肥胖指数和心脏代谢特征的遗传性和遗传相关性。

IF 1 4区 生物学 Q4 GENETICS & HEREDITY
Binbin Lin, Li Pan, Huijing He, Yaoda Hu, Ji Tu, Ling Zhang, Ze Cui, Xiaolan Ren, Xianghua Wang, Jing Nai, Guangliang Shan
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引用次数: 0

摘要

研究目的本研究旨在探讨中国核心家庭中各种肥胖指数的遗传率及其与心脏代谢特质的共同遗传因素:方法:本横断面研究共纳入了来自 538 个核心家庭的 1270 名个体。方法:这项横断面研究共纳入了来自 538 个核心家庭的 1270 名个体,采用了不同的指标来量化脂肪的质量和分布,包括体质指数(BMI)、内脏脂肪指数(VFI)和体脂率(BFP)。所有数量性状的遗传率和遗传相关性都是通过方差成分模型估算的。易感性-阈值模型用于估计二元性状的遗传率:结果:肥胖指数的遗传率估计值以 BMI(59%)最高,其次是 BFP(49%)和 VFI(40%)。连续性心脏代谢特征的遗传率估计值从 24% 到 50% 不等。所有肥胖特征都与血压、空腹血糖和尿酸呈持续显著的正遗传相关(rG 范围:0.26-0.57)。然而,在各种肥胖指数和血脂谱之间也观察到不同的遗传相关性。显著的遗传相关性仅限于特定配对:结论:各种肥胖指数与血脂谱之间的遗传相关性存在重叠:结论:各种肥胖指数和心血管代谢特征之间的遗传重叠凸显了多效应基因的重要性。结论:各种肥胖指数与心脏代谢特征之间的遗传重叠强调了多效基因的重要性,有必要开展进一步研究,以调查肥胖与心脏代谢疾病之间特定的共同遗传和环境因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Heritability and genetic correlations of obesity indices and cardiometabolic traits in the Northern Chinese families.

Objective: This study aimed to investigate the heritability of various obesity indices and their shared genetic factors with cardiometabolic traits in the Chinese nuclear family.

Methods: A total of 1270 individuals from 538 nuclear families were included in this cross-sectional study. Different indices were used to quantify fat mass and distribution, including body index mass (BMI), visceral fat index (VFI), and body fat percent (BFP). Heritability and genetic correlations for all quantitative traits were estimated using variance component models. The susceptibility-threshold model was utilized to estimate the heritability for binary traits.

Results: Heritability estimates for obesity indices were highest for BMI (59%), followed by BFP (49%), and VFI (40%). Heritability estimates for continuous cardiometabolic traits varied from 24% to 50%. All obesity measures exhibited consistently significant positive genetic correlations with blood pressure, fasting blood glucose, and uric acid (rG range: 0.26-0.57). However, diverse genetic correlations between various obesity indices and lipid profiles were observed. Significant genetic correlations were limited to specific pairs: BFP and total cholesterol (rG = 0.24), BFP and low-density lipoprotein cholesterol (rG = 0.25), and VFI and triglyceride (rG = 0.33).

Conclusion: The genetic overlap between various obesity indices and cardiometabolic traits underscores the importance of pleiotropic genes. Further studies are warranted to investigate specific shared genetic and environmental factors between obesity and cardiometabolic diseases.

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来源期刊
Annals of Human Genetics
Annals of Human Genetics 生物-遗传学
CiteScore
4.20
自引率
0.00%
发文量
34
审稿时长
3 months
期刊介绍: Annals of Human Genetics publishes material directly concerned with human genetics or the application of scientific principles and techniques to any aspect of human inheritance. Papers that describe work on other species that may be relevant to human genetics will also be considered. Mathematical models should include examples of application to data where possible. Authors are welcome to submit Supporting Information, such as data sets or additional figures or tables, that will not be published in the print edition of the journal, but which will be viewable via the online edition and stored on the website.
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