乙酸酯的救星乙酰-CoA 促进胎盘发育

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-09-05 DOI:10.1016/j.stem.2024.08.003

Joseph Festa, Sophie Trefely

引用次数: 0

摘要

在胎盘调节母体和胎儿之间营养交换的同时，Yu 等人揭示了人类胎盘发育本身对营养敏感。他们阐明了驱动胎盘合胞化的新陈代谢和表观遗传转变的纠缠，并确定了对代谢物乙酰-CoA的需求，而乙酰-CoA对葡萄糖代谢很敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Acetate to the rescue: Acetyl-CoA facilitates placental development

While the placenta regulates nutritional exchange between mother and fetus, Yu et al. reveal that human placental development is itself nutrient-sensitive. They elucidate entwined metabolic and epigenetic transitions driving syncytialization and pinpoint a requirement for the metabolite acetyl-CoA, which is sensitive to glucose metabolism.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.