关于产后卵子生成的可能性,你站在哪一边?

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
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引用次数: 0

摘要

众所周知,卵母细胞是在胎儿发育过程中产生的,初级卵泡的总数在出生时就已确定。在人类,卵泡在出生后不断减少,直到两岁左右。在青春期减数分裂恢复之前,卵泡数量一直保持不变,卵母细胞也不会更新;由于没有合适的技术来检测和获取干细胞,这一教条在上个世纪一直被保留下来。然而,根据干细胞标记,一些科学家在发育中和成年的人类卵巢组织中检测到了干细胞,特别是在卵巢表面上皮细胞中。此外,许多采用不同方法策略的学者也指出了这种可能性。这些证据促使许多科学家对这一假说进行了探索,但目前还没有明确的共识接受这一观点。有趣的是,从成熟卵巢和其他干细胞组织来源提取卵母细胞,促进了提取成熟卵母细胞策略的发展,有助于辅助生殖技术的应用。在此,我们回顾了有关成年女性卵母细胞新生的证据和争议;此外,我们也同意这一观点,即这一过程可能发生在成年期,其改变可能与女性的各种病症有关,如多囊卵巢综合征、卵巢早衰、卵巢储备功能减退以及一些不孕症和遗传性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Which side of the coin are you on regarding possible postnatal oogenesis?

It is well known that oocytes are produced during fetal development and that the total number of primary follicles is determined at birth. In humans, there is a constant loss of follicles after birth until about two years of age. The number of follicles is preserved until the resumption of meiosis at puberty and there is no renewal of the oocytes; this dogma was maintained in the last century because there were no suitable techniques to detect and obtain stem cells. However, following stem cell markers, several scientists have detected them in developing and adult human ovarian tissues, especially in the ovarian surface epithelial cells. Furthermore, many authors using different methodological strategies have indicated this possibility. This evidence has led many scientists to explore this hypothesis; there is no definitive consensus to accept this idea. Interestingly, oocyte retrieval from mature ovaries and other tissue sources of stem cells has contributed to the development of strategies for the retrieval of mature oocytes, useful for assisted reproductive technology. Here, we review the evidence and controversies on oocyte neooogenesis in adult women; in addition, we agree with the idea that this process may occur in adulthood and that its alteration may be related to various pathologies in women, such as polycystic ovary syndrome, premature ovarian insufficiency, diminished ovarian reserve and several infertility and genetic disorders.

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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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