圣约翰草的特殊新陈代谢

IF 8.3 2区 生物学 Q1 PLANT SCIENCES
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引用次数: 0

摘要

圣约翰草(Hypericum perforatum L.)的特殊新陈代谢是药用植物研究的一个重点,因为它具有标志性的生物活性化合物金丝桃素(hyperforin)和金丝桃素(hypericin)。圣约翰草的传统药用价值可追溯到古代,目前被用于轻度抑郁症的治疗。最近的研究工作揭示了这种植物中各种代谢物的生物合成过程,如类黄酮、黄酮、金丝桃素和金丝桃甙。对这些途径的阐明,以及新酶(如金丝桃素合成酶)的发现,为制药研究提供了支持,使生物活性化合物的规模化生产成为可能,从而有助于新药的开发。以单细胞 RNA-seq 为基础阐明金丝桃素的生物合成是一种可扩展的方法,它将加速植物特殊代谢产物的基因发现和全途径重组。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Specialized metabolism in St John's wort

The specialized metabolism of St. John's wort, Hypericum perforatum L., is a key focus in medicinal plant research due to its hallmark bioactive compounds hyperforin and hypericin. Known for its traditional medicinal uses dating back to ancient times, St. John's wort is currently used for mild depression therapy. Recent research works have shed light on the biosynthesis of various metabolites in this plant, such as flavonoids, xanthones, hyperforin, and hypericin. The elucidation of these pathways, along with the discovery of novel enzymes like hyperforin synthase, support the pharmaceutical research by enabling scalable production of bioactive compounds for the development of new drugs. Elucidation of the hyperforin biosynthesis based on single-cell RNA-seq is an approach that will be expanded and accelerate the gene discovery and full pathway reconstitution of plant specialized metabolites.

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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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